{"id":1017,"date":"2017-09-05T21:20:30","date_gmt":"2017-09-06T01:20:30","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/?post_type=chapter&#038;p=1017"},"modified":"2018-07-20T19:36:16","modified_gmt":"2018-07-20T23:36:16","slug":"28-6-lactation","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/chapter\/28-6-lactation\/","title":{"raw":"28.6 Lactation","rendered":"28.6 Lactation"},"content":{"raw":"<div class=\"bcc-box bcc-highlight\">\r\n<h3>Learning Objectives<\/h3>\r\nBy the end of this section, you will be able to:\r\n<ul>\r\n \t<li>Describe the roles of the following hormones in lactation:\r\n<ul>\r\n \t<li>Estrogen<\/li>\r\n \t<li>Progesterone<\/li>\r\n \t<li>Prolactin<\/li>\r\n \t<li>Oxytocin<\/li>\r\n<\/ul>\r\n<\/li>\r\n \t<li>Describe the hormonal changes involved in breast development<\/li>\r\n \t<li>Describe the hormonal changes involved in lactation<\/li>\r\n<\/ul>\r\n<\/div>\r\n<strong>Lactation<\/strong> is the process by which milk is synthesized and secreted from the mammary glands of the postpartum female breast in response to an infant sucking at the nipple. Breast milk provides ideal nutrition and passive immunity for the infant, encourages mild uterine contractions to return the uterus to its pre-pregnancy size (i.e., involution), and induces a substantial metabolic increase in the mother, consuming the fat reserves stored during pregnancy.\r\n\r\n<section id=\"fs-id1962211\">\r\n<h1>Structure of the Lactating Breast<\/h1>\r\n<p id=\"fs-id2142783\">Mammary glands are modified sweat glands. The non-pregnant and non-lactating female breast is composed primarily of adipose and collagenous tissue, with mammary glands making up a very minor proportion of breast volume. The mammary gland is composed of milk-transporting lactiferous ducts, which expand and branch extensively during pregnancy in response to estrogen, growth hormone, cortisol, and prolactin. Moreover, in response to progesterone, clusters of breast alveoli bud from the ducts and expand outward toward the chest wall. Breast alveoli are balloon-like structures lined with milk-secreting cuboidal cells, or lactocytes, that are surrounded by a net of contractile myoepithelial cells. Milk is secreted from the lactocytes, fills the alveoli, and is squeezed into the ducts. Clusters of alveoli that drain to a common duct are called lobules; the lactating female has 12\u201320 lobules organized radially around the nipple. Milk drains from lactiferous ducts into lactiferous sinuses that meet at 4 to 18 perforations in the nipple, called nipple pores. The small bumps of the areola (the darkened skin around the nipple) are called Montgomery glands. They secrete oil to cleanse the nipple opening and prevent chapping and cracking of the nipple during breastfeeding.<\/p>\r\n\r\n<\/section><section id=\"fs-id2110788\">\r\n<h1>The Process of Lactation<\/h1>\r\n<p id=\"fs-id2023470\">The pituitary hormone <strong>prolactin<\/strong> is instrumental in the establishment and maintenance of breast milk supply. It also is important for the mobilization of maternal micronutrients for breast milk.<\/p>\r\n<p id=\"fs-id2306035\">Near the fifth week of pregnancy, the level of circulating prolactin begins to increase, eventually rising to approximately 10\u201320 times the pre-pregnancy concentration. We noted earlier that, during pregnancy, prolactin and other hormones prepare the breasts anatomically for the secretion of milk. The level of prolactin plateaus in late pregnancy, at a level high enough to initiate milk production. However, estrogen, progesterone, and other placental hormones inhibit prolactin-mediated milk synthesis during pregnancy. It is not until the placenta is expelled that this inhibition is lifted and milk production commences.<\/p>\r\n<p id=\"fs-id1289845\">After childbirth, the baseline prolactin level drops sharply, but it is restored for a 1-hour spike during each feeding to stimulate the production of milk for the next feeding. With each prolactin spike, estrogen and progesterone also increase slightly.<\/p>\r\n<p id=\"fs-id1636266\">When the infant suckles, sensory nerve fibers in the areola trigger a neuroendocrine reflex that results in milk secretion from lactocytes into the alveoli. The posterior pituitary releases oxytocin, which stimulates myoepithelial cells to squeeze milk from the alveoli so it can drain into the lactiferous ducts, collect in the lactiferous sinuses, and discharge through the nipple pores. It takes less than 1 minute from the time when an infant begins suckling (the latent period) until milk is secreted (the let-down). <a class=\"autogenerated-content\" href=\"#fig-ch29_06_01\">Figure 1<\/a> summarizes the positive feedback loop of the <strong>let-down reflex<\/strong>.<\/p>\r\n\r\n<figure id=\"fig-ch29_06_01\">\r\n<div class=\"title\"><\/div>\r\n<figcaption><\/figcaption>\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"550\"]<img src=\"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-content\/uploads\/sites\/150\/2017\/08\/2922_Let_Down_Reflex-new.jpg\" alt=\"This figure shows the process of let down reflex, the process in which the brain receives sensory impulses to release the hormones necessary for producing and discharging milk to the suckling newborn.\" width=\"550\" height=\"2765\" \/> Figure 1. Let-Down Reflex. A positive feedback loop ensures continued milk production as long as the infant continues to breastfeed.[\/caption]<\/figure>\r\n<p id=\"fs-id1291591\">The prolactin-mediated synthesis of milk changes with time. Frequent milk removal by breastfeeding (or pumping) will maintain high circulating prolactin levels for several months. However, even with continued breastfeeding, baseline prolactin will decrease over time to its pre-pregnancy level. In addition to prolactin and oxytocin, growth hormone, cortisol, parathyroid hormone, and insulin contribute to lactation, in part by facilitating the transport of maternal amino acids, fatty acids, glucose, and calcium to breast milk.<\/p>\r\n\r\n<\/section><section id=\"fs-id1277236\">\r\n<h1>Changes in the Composition of Breast Milk<\/h1>\r\n<p id=\"fs-id2301864\">In the final weeks of pregnancy, the alveoli swell with <strong>colostrum<\/strong>, a thick, yellowish substance that is high in protein but contains less fat and glucose than mature breast milk (<a class=\"autogenerated-content\" href=\"#tbl-ch29_03\">Table 3<\/a>). Before childbirth, some women experience leakage of colostrum from the nipples. In contrast, mature breast milk does not leak during pregnancy and is not secreted until several days after childbirth.<\/p>\r\n\r\n<table id=\"tbl-ch29_03\" summary=\"\"><caption>*Cow\u2019s milk should never be given to an infant. Its composition is not suitable and its proteins are difficult for the infant to digest.<\/caption>\r\n<thead>\r\n<tr>\r\n<th colspan=\"4\">Compositions of Human Colostrum, Mature Breast Milk, and Cow\u2019s Milk (g\/L) (Table 3)<\/th>\r\n<\/tr>\r\n<tr>\r\n<th><\/th>\r\n<th>Human colostrum<\/th>\r\n<th>Human breast milk<\/th>\r\n<th>Cow\u2019s milk*<\/th>\r\n<\/tr>\r\n<\/thead>\r\n<tbody>\r\n<tr>\r\n<td><strong>Total protein<\/strong><\/td>\r\n<td>23<\/td>\r\n<td>11<\/td>\r\n<td>31<\/td>\r\n<\/tr>\r\n<tr>\r\n<td><strong>Immunoglobulins<\/strong><\/td>\r\n<td>19<\/td>\r\n<td>0.1<\/td>\r\n<td>1<\/td>\r\n<\/tr>\r\n<tr>\r\n<td><strong>Fat<\/strong><\/td>\r\n<td>30<\/td>\r\n<td>45<\/td>\r\n<td>38<\/td>\r\n<\/tr>\r\n<tr>\r\n<td><strong>Lactose<\/strong><\/td>\r\n<td>57<\/td>\r\n<td>71<\/td>\r\n<td>47<\/td>\r\n<\/tr>\r\n<tr>\r\n<td><strong>Calcium<\/strong><\/td>\r\n<td>0.5<\/td>\r\n<td>0.3<\/td>\r\n<td>1.4<\/td>\r\n<\/tr>\r\n<tr>\r\n<td><strong>Phosphorus<\/strong><\/td>\r\n<td>0.16<\/td>\r\n<td>0.14<\/td>\r\n<td>0.90<\/td>\r\n<\/tr>\r\n<tr>\r\n<td><strong>Sodium<\/strong><\/td>\r\n<td>0.50<\/td>\r\n<td>0.15<\/td>\r\n<td>0.41<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<p id=\"fs-id2339243\">Colostrum is secreted during the first 48\u201372 hours postpartum. Only a small volume of colostrum is produced\u2014approximately 3 ounces in a 24-hour period\u2014but it is sufficient for the newborn in the first few days of life. Colostrum is rich with immunoglobulins, which confer gastrointestinal, and also likely systemic, immunity as the newborn adjusts to a nonsterile environment.<\/p>\r\n<p id=\"fs-id2094541\">After about the third postpartum day, the mother secretes transitional milk that represents an intermediate between mature milk and colostrum. This is followed by mature milk from approximately postpartum day 10 (see <a class=\"autogenerated-content\" href=\"#tbl-ch29_03\">Table 3<\/a>). As you can see in the accompanying table, cow\u2019s milk is not a substitute for breast milk. It contains less lactose, less fat, and more protein and minerals. Moreover, the proteins in cow\u2019s milk are difficult for an infant\u2019s immature digestive system to metabolize and absorb.<\/p>\r\nThe first few weeks of breastfeeding may involve leakage, soreness, and periods of milk engorgement as the relationship between milk supply and infant demand becomes established. Once this period is complete, the mother will produce approximately 1.5 liters of milk per day for a single infant, and more if she has twins or triplets. As the infant goes through growth spurts, the milk supply constantly adjusts to accommodate changes in demand. A woman can continue to lactate for years, but once breastfeeding is stopped for approximately 1 week, any remaining milk will be reabsorbed; in most cases, no more will be produced, even if suckling or pumping is resumed.\r\n<p id=\"fs-id2202983\">Mature milk changes from the beginning to the end of a feeding. The early milk, called <strong>foremilk<\/strong>, is watery, translucent, and rich in lactose and protein. Its purpose is to quench the infant\u2019s thirst. <strong>Hindmilk<\/strong> is delivered toward the end of a feeding. It is opaque, creamy, and rich in fat, and serves to satisfy the infant\u2019s appetite.<\/p>\r\nDuring the first days of a newborn\u2019s life, it is important for meconium to be cleared from the intestines and for bilirubin to be kept low in the circulation. Recall that bilirubin, a product of erythrocyte breakdown, is processed by the liver and secreted in bile. It enters the gastrointestinal tract and exits the body in the stool. Breast milk has laxative properties that help expel meconium from the intestines and clear bilirubin through the excretion of bile. A high concentration of bilirubin in the blood causes jaundice. Some degree of jaundice is normal in newborns, but a high level of bilirubin\u2014which is neurotoxic\u2014can cause brain damage. Newborns, who do not yet have a fully functional blood\u2013brain barrier, are highly vulnerable to the bilirubin circulating in the blood. Indeed, hyperbilirubinemia, a high level of circulating bilirubin, is the most common condition requiring medical attention in newborns. Newborns with hyperbilirubinemia are treated with phototherapy because UV light helps to break down the bilirubin quickly.\r\n\r\n<\/section>","rendered":"<div class=\"bcc-box bcc-highlight\">\n<h3>Learning Objectives<\/h3>\n<p>By the end of this section, you will be able to:<\/p>\n<ul>\n<li>Describe the roles of the following hormones in lactation:\n<ul>\n<li>Estrogen<\/li>\n<li>Progesterone<\/li>\n<li>Prolactin<\/li>\n<li>Oxytocin<\/li>\n<\/ul>\n<\/li>\n<li>Describe the hormonal changes involved in breast development<\/li>\n<li>Describe the hormonal changes involved in lactation<\/li>\n<\/ul>\n<\/div>\n<p><strong>Lactation<\/strong> is the process by which milk is synthesized and secreted from the mammary glands of the postpartum female breast in response to an infant sucking at the nipple. Breast milk provides ideal nutrition and passive immunity for the infant, encourages mild uterine contractions to return the uterus to its pre-pregnancy size (i.e., involution), and induces a substantial metabolic increase in the mother, consuming the fat reserves stored during pregnancy.<\/p>\n<section id=\"fs-id1962211\">\n<h1>Structure of the Lactating Breast<\/h1>\n<p id=\"fs-id2142783\">Mammary glands are modified sweat glands. The non-pregnant and non-lactating female breast is composed primarily of adipose and collagenous tissue, with mammary glands making up a very minor proportion of breast volume. The mammary gland is composed of milk-transporting lactiferous ducts, which expand and branch extensively during pregnancy in response to estrogen, growth hormone, cortisol, and prolactin. Moreover, in response to progesterone, clusters of breast alveoli bud from the ducts and expand outward toward the chest wall. Breast alveoli are balloon-like structures lined with milk-secreting cuboidal cells, or lactocytes, that are surrounded by a net of contractile myoepithelial cells. Milk is secreted from the lactocytes, fills the alveoli, and is squeezed into the ducts. Clusters of alveoli that drain to a common duct are called lobules; the lactating female has 12\u201320 lobules organized radially around the nipple. Milk drains from lactiferous ducts into lactiferous sinuses that meet at 4 to 18 perforations in the nipple, called nipple pores. The small bumps of the areola (the darkened skin around the nipple) are called Montgomery glands. They secrete oil to cleanse the nipple opening and prevent chapping and cracking of the nipple during breastfeeding.<\/p>\n<\/section>\n<section id=\"fs-id2110788\">\n<h1>The Process of Lactation<\/h1>\n<p id=\"fs-id2023470\">The pituitary hormone <strong>prolactin<\/strong> is instrumental in the establishment and maintenance of breast milk supply. It also is important for the mobilization of maternal micronutrients for breast milk.<\/p>\n<p id=\"fs-id2306035\">Near the fifth week of pregnancy, the level of circulating prolactin begins to increase, eventually rising to approximately 10\u201320 times the pre-pregnancy concentration. We noted earlier that, during pregnancy, prolactin and other hormones prepare the breasts anatomically for the secretion of milk. The level of prolactin plateaus in late pregnancy, at a level high enough to initiate milk production. However, estrogen, progesterone, and other placental hormones inhibit prolactin-mediated milk synthesis during pregnancy. It is not until the placenta is expelled that this inhibition is lifted and milk production commences.<\/p>\n<p id=\"fs-id1289845\">After childbirth, the baseline prolactin level drops sharply, but it is restored for a 1-hour spike during each feeding to stimulate the production of milk for the next feeding. With each prolactin spike, estrogen and progesterone also increase slightly.<\/p>\n<p id=\"fs-id1636266\">When the infant suckles, sensory nerve fibers in the areola trigger a neuroendocrine reflex that results in milk secretion from lactocytes into the alveoli. The posterior pituitary releases oxytocin, which stimulates myoepithelial cells to squeeze milk from the alveoli so it can drain into the lactiferous ducts, collect in the lactiferous sinuses, and discharge through the nipple pores. It takes less than 1 minute from the time when an infant begins suckling (the latent period) until milk is secreted (the let-down). <a class=\"autogenerated-content\" href=\"#fig-ch29_06_01\">Figure 1<\/a> summarizes the positive feedback loop of the <strong>let-down reflex<\/strong>.<\/p>\n<figure id=\"fig-ch29_06_01\">\n<div class=\"title\"><\/div><figcaption><\/figcaption><figure style=\"width: 550px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-content\/uploads\/sites\/150\/2017\/08\/2922_Let_Down_Reflex-new.jpg\" alt=\"This figure shows the process of let down reflex, the process in which the brain receives sensory impulses to release the hormones necessary for producing and discharging milk to the suckling newborn.\" width=\"550\" height=\"2765\" \/><figcaption class=\"wp-caption-text\">Figure 1. Let-Down Reflex. A positive feedback loop ensures continued milk production as long as the infant continues to breastfeed.<\/figcaption><\/figure>\n<\/figure>\n<p id=\"fs-id1291591\">The prolactin-mediated synthesis of milk changes with time. Frequent milk removal by breastfeeding (or pumping) will maintain high circulating prolactin levels for several months. However, even with continued breastfeeding, baseline prolactin will decrease over time to its pre-pregnancy level. In addition to prolactin and oxytocin, growth hormone, cortisol, parathyroid hormone, and insulin contribute to lactation, in part by facilitating the transport of maternal amino acids, fatty acids, glucose, and calcium to breast milk.<\/p>\n<\/section>\n<section id=\"fs-id1277236\">\n<h1>Changes in the Composition of Breast Milk<\/h1>\n<p id=\"fs-id2301864\">In the final weeks of pregnancy, the alveoli swell with <strong>colostrum<\/strong>, a thick, yellowish substance that is high in protein but contains less fat and glucose than mature breast milk (<a class=\"autogenerated-content\" href=\"#tbl-ch29_03\">Table 3<\/a>). Before childbirth, some women experience leakage of colostrum from the nipples. In contrast, mature breast milk does not leak during pregnancy and is not secreted until several days after childbirth.<\/p>\n<table id=\"tbl-ch29_03\" summary=\"\">\n<caption>*Cow\u2019s milk should never be given to an infant. Its composition is not suitable and its proteins are difficult for the infant to digest.<\/caption>\n<thead>\n<tr>\n<th colspan=\"4\">Compositions of Human Colostrum, Mature Breast Milk, and Cow\u2019s Milk (g\/L) (Table 3)<\/th>\n<\/tr>\n<tr>\n<th><\/th>\n<th>Human colostrum<\/th>\n<th>Human breast milk<\/th>\n<th>Cow\u2019s milk*<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Total protein<\/strong><\/td>\n<td>23<\/td>\n<td>11<\/td>\n<td>31<\/td>\n<\/tr>\n<tr>\n<td><strong>Immunoglobulins<\/strong><\/td>\n<td>19<\/td>\n<td>0.1<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td><strong>Fat<\/strong><\/td>\n<td>30<\/td>\n<td>45<\/td>\n<td>38<\/td>\n<\/tr>\n<tr>\n<td><strong>Lactose<\/strong><\/td>\n<td>57<\/td>\n<td>71<\/td>\n<td>47<\/td>\n<\/tr>\n<tr>\n<td><strong>Calcium<\/strong><\/td>\n<td>0.5<\/td>\n<td>0.3<\/td>\n<td>1.4<\/td>\n<\/tr>\n<tr>\n<td><strong>Phosphorus<\/strong><\/td>\n<td>0.16<\/td>\n<td>0.14<\/td>\n<td>0.90<\/td>\n<\/tr>\n<tr>\n<td><strong>Sodium<\/strong><\/td>\n<td>0.50<\/td>\n<td>0.15<\/td>\n<td>0.41<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p id=\"fs-id2339243\">Colostrum is secreted during the first 48\u201372 hours postpartum. Only a small volume of colostrum is produced\u2014approximately 3 ounces in a 24-hour period\u2014but it is sufficient for the newborn in the first few days of life. Colostrum is rich with immunoglobulins, which confer gastrointestinal, and also likely systemic, immunity as the newborn adjusts to a nonsterile environment.<\/p>\n<p id=\"fs-id2094541\">After about the third postpartum day, the mother secretes transitional milk that represents an intermediate between mature milk and colostrum. This is followed by mature milk from approximately postpartum day 10 (see <a class=\"autogenerated-content\" href=\"#tbl-ch29_03\">Table 3<\/a>). As you can see in the accompanying table, cow\u2019s milk is not a substitute for breast milk. It contains less lactose, less fat, and more protein and minerals. Moreover, the proteins in cow\u2019s milk are difficult for an infant\u2019s immature digestive system to metabolize and absorb.<\/p>\n<p>The first few weeks of breastfeeding may involve leakage, soreness, and periods of milk engorgement as the relationship between milk supply and infant demand becomes established. Once this period is complete, the mother will produce approximately 1.5 liters of milk per day for a single infant, and more if she has twins or triplets. As the infant goes through growth spurts, the milk supply constantly adjusts to accommodate changes in demand. A woman can continue to lactate for years, but once breastfeeding is stopped for approximately 1 week, any remaining milk will be reabsorbed; in most cases, no more will be produced, even if suckling or pumping is resumed.<\/p>\n<p id=\"fs-id2202983\">Mature milk changes from the beginning to the end of a feeding. The early milk, called <strong>foremilk<\/strong>, is watery, translucent, and rich in lactose and protein. Its purpose is to quench the infant\u2019s thirst. <strong>Hindmilk<\/strong> is delivered toward the end of a feeding. It is opaque, creamy, and rich in fat, and serves to satisfy the infant\u2019s appetite.<\/p>\n<p>During the first days of a newborn\u2019s life, it is important for meconium to be cleared from the intestines and for bilirubin to be kept low in the circulation. Recall that bilirubin, a product of erythrocyte breakdown, is processed by the liver and secreted in bile. It enters the gastrointestinal tract and exits the body in the stool. Breast milk has laxative properties that help expel meconium from the intestines and clear bilirubin through the excretion of bile. A high concentration of bilirubin in the blood causes jaundice. Some degree of jaundice is normal in newborns, but a high level of bilirubin\u2014which is neurotoxic\u2014can cause brain damage. Newborns, who do not yet have a fully functional blood\u2013brain barrier, are highly vulnerable to the bilirubin circulating in the blood. Indeed, hyperbilirubinemia, a high level of circulating bilirubin, is the most common condition requiring medical attention in newborns. Newborns with hyperbilirubinemia are treated with phototherapy because UV light helps to break down the bilirubin quickly.<\/p>\n<\/section>\n","protected":false},"author":10,"menu_order":6,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-1017","chapter","type-chapter","status-publish","hentry"],"part":984,"_links":{"self":[{"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/chapters\/1017","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/wp\/v2\/users\/10"}],"version-history":[{"count":3,"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/chapters\/1017\/revisions"}],"predecessor-version":[{"id":1368,"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/chapters\/1017\/revisions\/1368"}],"part":[{"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/parts\/984"}],"metadata":[{"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/chapters\/1017\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/wp\/v2\/media?parent=1017"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/pressbooks\/v2\/chapter-type?post=1017"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/wp\/v2\/contributor?post=1017"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/dcbiol12031209\/wp-json\/wp\/v2\/license?post=1017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}