{"id":77,"date":"2020-04-18T23:27:54","date_gmt":"2020-04-19T03:27:54","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/humannutrition\/chapter\/the-digestive-system-2-2\/"},"modified":"2025-12-04T13:09:17","modified_gmt":"2025-12-04T18:09:17","slug":"the-digestive-system-2-2","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/humannutrition\/chapter\/the-digestive-system-2-2\/","title":{"raw":"The Gastrointestinal Tract and the Digestive System","rendered":"The Gastrointestinal Tract and the Digestive System"},"content":{"raw":"
\r\n

What Happens to the Food You Eat?<\/h3>\r\n<\/header>\r\n
\r\n\r\nWhen you ingest food, a 3-part process takes place:\r\n
    \r\n \t
  1. Digestion<\/strong>: The process of breaking down food into smaller molecules, which can occur mechanically or chemically.<\/li>\r\n \t
  2. Absorption<\/strong>: The process of taking these smaller molecules from the gastrointestinal tract through the intestinal wall and into the circulation (e.g., blood or lymph).<\/li>\r\n \t
  3. Elimination<\/strong>: The removal of undigested or unabsorbed food and waste products.<\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\nOnce you have eaten, your digestive system starts the process that breaks down the components of food into smaller components that can be absorbed and taken into the body. To do this, the digestive system functions on two levels, mechanically to move and mix ingested food, and chemically to break down large molecules. The smaller nutrient molecules can then be absorbed and processed by cells throughout the body for energy or used as building blocks for new cells.\r\n\r\n \r\n\r\n[caption id=\"attachment_70\" align=\"aligncenter\" width=\"348\"]\"The Figure 3.2 Digestion Breakdown of Macronutrients.[\/caption]\r\n\r\nDigestion converts components of the food we eat into smaller molecules that can be absorbed into the body and utilized for energy needs or as building blocks for making larger molecules in cells. Nutrients, as well as some non-nutrients, are absorbed. Anything that isn't absorbed into the body, such as fibre, is excreted\/eliminated.\r\n

    The Gastrointestinal (GI) tract<\/h1>\r\nThe GI tract is a tube-like structure that starts at the mouth and ends at the anus, including everything in between.\r\n\r\n \r\n\r\n[caption id=\"attachment_72\" align=\"aligncenter\" width=\"949\"]\"An Figure 3.3 The human digestive system.[\/caption]\r\n\r\nThere are several distinct sections of the GI tract that play a role in digestion, absorption, and elimination:\r\n
      \r\n \t
    1. Mouth<\/li>\r\n \t
    2. Esophagus<\/li>\r\n \t
    3. Stomach<\/li>\r\n \t
    4. Small intestine<\/li>\r\n \t
    5. Large intestine<\/li>\r\n<\/ol>\r\nMovement between these sections is controlled by sphincters, which are rings of muscle that respond to nerve signals, causing them to open or close. Smooth muscle tissue surrounds the GI tract and its contraction produces waves, known as peristalsis or haustration, that propel food through the tract.\r\n\r\nSeveral accessory organs also play a role in the digestion and absorption of nutrients:\r\n
        \r\n \t
      1. Salivary glands<\/li>\r\n \t
      2. Liver<\/li>\r\n \t
      3. Pancreas<\/li>\r\n \t
      4. Gall bladder<\/li>\r\n<\/ol>\r\nThe GI tract is lined with mucosal tissue that secretes digestive juices (which aid in the breakdown of food) and mucus (which facilitates the propulsion of food through the tract).\r\n

        From the Brain to the Stomach<\/h1>\r\n

        The Cephalic Phase of Digestion<\/h2>\r\nThe process of digestion begins even before you put food into your mouth. The cephalic phase<\/strong> of digestion begins when you start thinking about food. When you feel hungry, your body sends a message to your brain that it is time to eat. Sights and smells influence your body\u2019s preparedness for food. Smelling food sends a message to your brain. Your brain then tells the mouth to get ready, you start salivating, and your stomach starts secreting gastric juices in preparation for your meal. Specifically, the cells lining the stomach will secrete the hormone gastrin, which stimulates the gastric glands to secrete digestive juices.\r\n

        The Mouth<\/h2>\r\nIn the mouth, where the second step of digestion starts, the mechanical and chemical breakdown of food begins. The chemical breakdown of food involves enzymes such as salivary amylase, which starts the breakdown of large starch molecules into smaller components. Lingual lipase, produce in the mouth, helps to initiate the breakdown of lipids. Some lipid breakdown occurs in the mouth, but more occurs in the stomach as the enzyme operates optimally in the acidic stomach environment.\r\n\r\nMechanical breakdown starts with mastication (chewing) in the mouth, which moistens the food, increases its surface area, mixes it together, and stimulates the production of saliva. Saliva provides lubrication and enables food movement downward. The slippery mass of partially broken-down food is called a bolus, which moves down the digestive tract as you swallow. Swallowing may seem voluntary at first because it requires conscious effort to push the food with the tongue back toward the throat, but after this, swallowing proceeds involuntarily, meaning it cannot be stopped once it begins. As you swallow, the bolus is pushed from the mouth through the pharynx and into a muscular tube called the esophagus. As the bolus travels through the pharynx, a small flap called the epiglottis closes to prevent choking by keeping food from going into the trachea.\r\n
        \r\n

        Digestive Enzymes<\/h3>\r\n<\/header>\r\n
        \r\n\r\nEnzymes play a key role in chemical digestion.\r\n
          \r\n \t
        1. Amylases<\/strong> break down carbohydrates<\/strong><\/li>\r\n \t
        2. Lipases<\/strong> break down lipids<\/strong><\/li>\r\n \t
        3. Proteases<\/strong> break down proteins<\/strong><\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n

          The Esophagus<\/h2>\r\nIn addition to the epiglottis closing, the upper esophageal sphincter (a sphincter at the top of the esophagus; Figure 3.4 \"The trachea, the esophagus and its associated sphincters\") needs to open, to allow the bolus to enter the esophagus. The esophagus is a muscular tube connecting the pharynx (throat) to the stomach and transports the bolus of food between these two sections. In an action known as peristalsis<\/strong><\/em>, the muscles of the esophagus contract to squeeze and push the food bolus down to the stomach (Figure 3.5 \"Peristalsis in the esophagus\").\r\n\r\n \r\n\r\n[caption id=\"attachment_1165\" align=\"aligncenter\" width=\"619\"]\"The Figure 3.4 The trachea, the esophagus and its associated sphincters.[\/caption]\r\n\r\n \r\n\r\n[caption id=\"attachment_73\" align=\"aligncenter\" width=\"763\"]\"Peristalsis\" Figure 3.5 Peristalsis in the esophagus.[\/caption]\r\n

          The Stomach<\/h2>\r\nAt the junction between the esophagus and stomach, there is a sphincter muscle, known as the gastroesophageal\u00a0 (or lower esophageal or cardiac) sphincter (Figure 3.4) that remains closed until the food bolus approaches. The pressure of the food bolus stimulates the lower esophageal sphincter to relax and open, allowing the food to move from the esophagus into the stomach. Solid food takes between four and eight seconds to travel down the esophagus, and liquids take about one second. When food enters the stomach, a highly muscular organ, powerful peristaltic contractions help mash, pulverize, and churn food into chyme, which is a semiliquid mass of partially digested food that also contains gastric juices. Even before the food arrives at the stomach, the cells lining the stomach will secrete the hormone gastrin, which stimulates the gastric glands to secrete digestive juices. Gastric glands contain two cell types, parietal cells and chief cells, that produce the components of gastric juice listed below:\r\n\r\n\r\n\r\n\r\n
          Table 3.1: The components of gastric juice, produced by the parietal and chief cells<\/caption>\r\n
          Parietal Cells<\/strong><\/td>\r\nChief Cells<\/strong><\/td>\r\n<\/tr>\r\n
          Hydrochloric acid: important for protein denaturation, killing bacteria\/ germs, and activating pepsinogen into pepsin<\/td>\r\nSecrete pepsinogen, pepsinogen is then converted to pepsin by hydrochloric acid, which is important for protein digestion.<\/td>\r\n<\/tr>\r\n
          Intrinsic factor: important for vitamin B12<\/sub> absorption<\/td>\r\nGastric lipase: important for lipid digestion<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\nThe length of time food spends in the stomach varies by the macronutrient composition of the meal. A high-fat or high-protein meal takes longer to break down than one rich in carbohydrates. It usually takes a few hours after a meal to empty the stomach contents completely into the small intestine. Minimal amounts of water, minerals, and drugs are absorbed in the stomach as the majority of absorption takes place in the small intestine.\r\n
          \r\n

          If the stomach contains acid, why doesn't the stomach lining always erode?<\/h3>\r\n<\/header>\r\n
          \u00a0The stomach contains cells that secrete bicarbonate and mucus to help neutralize acid near the surface of the stomach lining and provide a protective layer against hydrochloric acid.<\/div>\r\n<\/div>\r\n
          \r\n\r\nGastrointestinal Disorders: Heartburn and Gastroesophageal reflux disease (GERD)<\/span>\r\n\r\nWhen the gastroesophageal sphincter remains partially opened, this may cause gastric juice, which contains hydrochloric acid, to seep back into the esophagus. This can result in feelings of heartburn, or if it is more painful, frequent, and persistent, it can be classified as GERD. To try and reduce GERD, people are advised to identify triggers and avoid them, eat smaller meals, wait for a few hours before lying down (and consider raising their head), or take medications (e.g., antacids or proton pump inhibitors). If left untreated, scar tissue can develop in the esophagus, making it hard to swallow and even aggravating asthma.\r\n\r\n<\/div>\r\n

          The Small Intestine and the Accessory Organs<\/h1>\r\nFrom the stomach, chyme passes into the small intestine with the pyloric sphincter separating these two sections (Figure 3.6). The small intestine is divided into three structural parts: the duodenum, the jejunum, and the ileum (Figure 3.7).\r\n\r\n \r\n\r\n[caption id=\"attachment_1058\" align=\"aligncenter\" width=\"1122\"]\"The Figure 3.6 The stomach and the small intestine.[\/caption]\r\n\r\n \r\n\r\n[caption id=\"attachment_1175\" align=\"aligncenter\" width=\"839\"]\"The Figure 3.7 Sections of the small intestine.[\/caption]\r\n

          The Accessory Organs: The Liver, Pancreas and Gall Bladder<\/h1>\r\nChemical digestion in the small intestine relies on 3 key accessory organs: the liver, gall bladder and pancreas. Once the chyme enters the duodenum (the first segment of the small intestine), this signals the release of secretin; the presence of protein and fat in the duodenum also signals the release of cholecystokinin (CCK)\u00a0 into the duodenum. This in turn signals the pancreas and gallbladder to release juices that assist in digestion.<\/span>\r\n\r\nSpecifically, following CCK secretion, \u00a0the gallbladder secretes bile (which is made in the liver but stored in the gall bladder), into the duodenum of the small intestine via the common bile duct (Figure 3.8).\u00a0 Bile\u2019s components emulsify fats and break them down into smaller droplets; it acts similar to how dish soap removes grease from a frying pan. This allows for the movement of fats in the watery environment of the small intestine.\r\n\r\n \r\n\r\n[caption id=\"attachment_1184\" align=\"aligncenter\" width=\"787\"]\"The Figure 3.8 The gallbladder.[\/caption]\r\n\r\n
          <\/div>\r\nAdditionally, following CCK secretion, the pancreas secretes pancreatic juices into the duodenum of the small intestine, via the pancreatic duct (Figure 3.9). This fluid consists mostly of water, but it also contains enzymes that further break down proteins (e.g., proteases), carbohydrates (e.g., pancreatic amylase), and lipids (e.g., pancreatic lipase). The pancreatic juices also contain bicarbonate ions that neutralize the acidity of the stomach-derived chyme, which helps the pancreatic enzymes work more effectively. Additionally, the pancreas produces insulin and glucagon which play a key role in blood glucose maintenance.\r\n\r\n \r\n\r\n[caption id=\"attachment_1183\" align=\"aligncenter\" width=\"637\"]\"The Figure 3.9 The pancreas.[\/caption]\r\n

          Nutrient Absorption<\/h1>\r\nWhen the digestive system has broken down food into its nutrient components, the body eagerly awaits delivery; for this to happen, the nutrients must be absorbed from the GI tract into the blood or lymph. The small intestine is the site of the most nutrient absorption. The heavily folded nature of this lining creates a large surface area to maximize nutrient absorption. The surface area is increased by folds, villi, and microvilli. Digested nutrients are absorbed into either capillaries or lymphatic vessels contained within each microvillus. Its surface area is greater than 200 square meters, which is about the size of a tennis court. The large surface area is due to the multiple levels of folding. The internal tissue of the small intestine is covered in villi, which are tiny finger-like projections that are covered with even smaller projections, called microvilli (Figure 3.10 \u201cStructure of the small intestine\").\r\n\r\nThe digested nutrients pass through the absorptive cells of the intestine via passive diffusion, facilitated diffusion or active transport. Water-soluble nutrients such as amino acids, short fatty acids, and monosaccharides (sugars) are transported from the intestinal cells into capillaries and then transported to the liver via the portal vein. Larger fatty acids, fat-soluble vitamins, and other lipids are transported by a more circuitous route through the lymphatic vessels, which eventually meet up with blood vessels. The lymphatic system is a one-way system of vessels that transports lymph, a fluid rich in white blood cells, and lipid-soluble substances after a meal containing lipids. The lymphatic system slowly moves its contents through the lymphatic vessels and empties into blood vessels in the upper chest area. Now, the absorbed lipid-soluble components are in the blood where they can be distributed throughout the body and utilized by cells (see Figure 3.11 \"The absorption of nutrients\").\r\n\r\n \r\n\r\n[caption id=\"attachment_75\" align=\"aligncenter\" width=\"1079\"]\"The Figure 3.10 Structure of the small intestine.[\/caption]\r\n\r\n \r\n\r\n[caption id=\"attachment_76\" align=\"aligncenter\" width=\"638\"]\"The Figure 3.11 The absorption of nutrients.[\/caption]\r\n\r\n
          Gastrointestinal Disorders: Ulcers and Celiac Disease<\/span><\/div>\r\n
          Ulcers\r\n<\/span>Areas of the GI tract can become eroded by hydrochloric acid and pepsin, which can result in an ulcer. Gastric ulcers are found in the stomach and duodenal ulcers can be found in the duodenum. When someone has an ulcer, they may experience burning pain 1-3 hours after eating, vomit blood, or have bloody stool. The helicobacter pylori bacteria <\/span>plays a key role in the development of ulcers and it is thought that this bacteria burrows through the layers of mucus to expose the underlying sensitive layers of tissue. Some ulcers may be caused by the prolonged use of non-steroidal anti-inflammatory drugs.\r\n<\/span><\/div>\r\n
          Celiac Disease\r\n<\/span>When someone with celiac disease ingests gluten, a protein found in wheat, barley, and rye, it causes an immune reaction, which, over time can damage the villi of the small intestine. As the small intestine is the major site of nutrient absorption, this can result in the malabsorption of nutrients. Symptoms of celiac disease may include bloating, gas, chronic diarrhea, lactose intolerance, nausea, vomiting, abdominal pain, or loose, greasy, bulk stool\r\n[footnote]https:\/\/www.niddk.nih.gov\/health-information\/digestive-diseases\/celiac-disease\/symptoms-causes[\/footnote].<\/span><\/div>\r\n

          Movement through the Small Intestine<\/h1>\r\nTwo different types of muscular contractions, called peristalsis and segmentation, control the movement and mixing of food in the small intestine. Similar to what occurs in the esophagus and stomach, peristalsis is circular waves of smooth muscle contraction that propel food forward. Segmentation from circular muscle contraction slows movement in the small intestine by forming temporary \u201csausage link\u201d type of segments that allow chyme to slosh food back and forth in both directions to promote mixing of the chyme and enhance absorption of nutrients (Figure 3.12 \"Segmentation\"). Almost all the components of food are completely broken down to their simplest units within the first 25 centimeters of the small intestine. Instead of proteins, carbohydrates, and lipids, the chyme now consists of amino acids, monosaccharides, and emulsified components of triglycerides.\r\n\r\n \r\n\r\n[caption id=\"attachment_74\" align=\"aligncenter\" width=\"274\"]\"Segmentation\" Figure 3.12 Segmentation[\/caption]\r\n

          From the Small Intestine to the Large Intestine<\/h1>\r\nThe process of digestion is fairly efficient. Any food that is still incompletely broken down (usually less than ten percent of food consumed) and the food\u2019s indigestible fibre content move from the small intestine to the large intestine (colon) through the ileocecal valve. The main task of the large intestine is to absorb much of the remaining water. Remember, water is present not only in solid foods and beverages, but the stomach also releases a few hundred milliliters of gastric juice, and the pancreas adds approximately 500 milliliters during the digestion of the meal. For the body to conserve water, excessive amounts of water mustn't be lost in fecal matter. In the large intestine, no further chemical or mechanical breakdown of food takes place unless it is accomplished by the bacteria that inhabit this portion of the intestinal tract. The number of bacteria residing in the large intestine is estimated to be greater than 1014, which is more than the total number of cells in the human body (1013). This may seem rather unpleasant, but the great majority of bacteria in the large intestine are harmless and many are even beneficial.\r\n\r\n \r\n\r\n \r\n\r\n[caption id=\"attachment_1177\" align=\"aligncenter\" width=\"633\"]\"The Figure 3.12 Sections of the large intestine.[\/caption]\r\n

          From the Large Intestine to the Anus<\/h1>\r\nAfter a few hours in the stomach, plus three to six hours in the small intestine, and about sixteen hours in the large intestine, the digestion process enters step four, which is the elimination of indigestible food matter as feces. Feces contain indigestible food components and gut bacteria (which comprise almost 50 percent of the content). It is stored in the rectum until it is expelled through the anus via defecation.\r\n

          Summary of the Functions of the Digestive Organs<\/h1>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
          Table 3.2: Summary of the functions of the digestive organs\u00a0<\/span><\/caption>\r\n
          Organ<\/th>\r\nMajor functions<\/th>\r\nOther functions<\/th>\r\n<\/tr>\r\n<\/thead>\r\n
          Mouth<\/td>\r\n\r\n
            \r\n \t
          • Ingests food<\/li>\r\n \t
          • Chews and mixes food<\/li>\r\n \t
          • Begins chemical breakdown of carbohydrates<\/li>\r\n \t
          • Moves food into the pharynx<\/li>\r\n \t
          • Produces lingual lipase<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Moistens and dissolves food, allowing you to taste it<\/li>\r\n \t
          • Cleans and lubricates the teeth and oral cavity<\/li>\r\n \t
          • Has some antimicrobial activity<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Pharynx<\/td>\r\n\r\n
            \r\n \t
          • Propels food from the oral cavity to the esophagus<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Lubricates food and passageways<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Esophagus<\/td>\r\n\r\n
            \r\n \t
          • Propels food to the stomach<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Lubricates food and passageways<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Stomach<\/td>\r\n\r\n
            \r\n \t
          • Mixes and churns food with gastric juices to form chyme<\/li>\r\n \t
          • Begins chemical breakdown of proteins and some fats<\/li>\r\n \t
          • Releases food into the duodenum as chyme<\/li>\r\n \t
          • Absorbs some fat-soluble substances (for example, alcohol, aspirin)<\/li>\r\n \t
          • Possesses antimicrobial functions<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Stimulates protein-digesting enzymes<\/li>\r\n \t
          • Secretes intrinsic factor required for vitamin B12<\/sub> absorption in the small intestine<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Small intestine<\/td>\r\n\r\n
            \r\n \t
          • Mixes chyme with digestive juices<\/li>\r\n \t
          • Propels food at a rate slow enough for digestion and absorption<\/li>\r\n \t
          • Absorbs breakdown products of carbohydrates, proteins, lipids, and nucleic acids, along with vitamins, minerals, and water<\/li>\r\n \t
          • Performs physical digestion via segmentation<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Provides an optimal medium for enzymatic activity<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Accessory organs<\/td>\r\n\r\n
            \r\n \t
          • Liver: produces bile salts, which emulsify lipids, aiding their digestion and absorption<\/li>\r\n \t
          • Gallbladder: stores, concentrates, and releases bile<\/li>\r\n \t
          • Pancreas: produces digestive enzymes and bicarbonate<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Bicarbonate-rich pancreatic juices help neutralize acidic chyme and provide the optimal environment for enzymatic activity<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Large intestine<\/td>\r\n\r\n
            \r\n \t
          • Further breaks down food residues<\/li>\r\n \t
          • Absorbs most residual water, electrolytes, and vitamins produced by enteric bacteria<\/li>\r\n \t
          • Propels feces toward the rectum<\/li>\r\n \t
          • Eliminates feces<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Food residue is concentrated and temporarily stored prior to defecation<\/li>\r\n \t
          • Mucus eases the passage of feces through the colon<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Data source: (\"Digestive system processes and regulation,\" 2022)[footnote]Table accessed for free at: https:\/\/openstax.org\/books\/anatomy-and-physiology-2e\/pages\/23-2-digestive-system-processes-and-regulation[\/footnote]<\/span><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n \r\n

          Summary of Enzymes and Hormones Involved in Digestion<\/h1>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
          Table<\/span> 3.3:\u00a0Enzymes involved in digestion <\/span><\/caption>\r\n
          Category<\/th>\r\nEnzyme Name<\/th>\r\nSource<\/th>\r\nSubstrate<\/th>\r\nProduct<\/th>\r\n<\/tr>\r\n<\/thead>\r\n
          Salivary Enzymes<\/td>\r\nLingual lipase<\/td>\r\nLingual glands<\/td>\r\nTriglycerides<\/td>\r\nFree fatty acids, and mono- and diglycerides<\/td>\r\n<\/tr>\r\n
          Salivary Enzymes<\/td>\r\nSalivary amylase<\/td>\r\nSalivary glands<\/td>\r\nPolysaccharides<\/td>\r\nDisaccharides and trisaccharides<\/td>\r\n<\/tr>\r\n
          Gastric enzymes<\/td>\r\nGastric lipase<\/td>\r\nChief cells<\/td>\r\nTriglycerides<\/td>\r\nFatty acids and monoacylglycerides<\/td>\r\n<\/tr>\r\n
          Gastric enzymes<\/td>\r\nPepsin*<\/td>\r\nChief cells<\/td>\r\nProteins<\/td>\r\nPeptides<\/td>\r\n<\/tr>\r\n
          Brush border enzymes<\/td>\r\nLactase<\/td>\r\nSmall intestine<\/td>\r\nLactose<\/td>\r\nGlucose and galactose<\/td>\r\n<\/tr>\r\n
          Brush border enzymes<\/td>\r\nMaltase<\/td>\r\nSmall intestine<\/td>\r\nMaltose<\/td>\r\nGlucose<\/td>\r\n<\/tr>\r\n
          Brush border enzymes<\/td>\r\nSucrase<\/td>\r\nSmall intestine<\/td>\r\nSucrose<\/td>\r\nGlucose and fructose<\/td>\r\n<\/tr>\r\n
          Brush border enzymes<\/td>\r\nPeptidases<\/td>\r\nSmall intestine<\/td>\r\n\r\n
            \r\n \t
          • Aminopeptidase: amino acids at the amino end of peptides<\/li>\r\n \t
          • Dipeptidase: dipeptides<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		\r\n
            \r\n \t
          • Aminopeptidase: amino acids and peptides<\/li>\r\n \t
          • Dipeptidase: amino acids<\/li>\r\n<\/ul>\r\n<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nCarboxy-peptidase*<\/td>\r\nPancreatic acinar cells<\/td>\r\nAmino acids at the carboxyl end of peptides<\/td>\r\nAmino acids and peptides<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nChymotrypsin*<\/td>\r\nPancreatic acinar cells<\/td>\r\nProteins<\/td>\r\nPeptides<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nElastase*<\/td>\r\nPancreatic acinar cells<\/td>\r\nProteins<\/td>\r\nPeptides<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nNucleases<\/td>\r\nPancreatic acinar cells<\/td>\r\n\r\n
            \r\n \t
          • Ribonuclease: ribonucleic acids<\/li>\r\n \t
          • Deoxyribonuclease: deoxyribonucleic acids<\/li>\r\n<\/ul>\r\n<\/td>\r\n
          		Nucleotides<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nPancreatic amylase<\/td>\r\nPancreatic acinar cells<\/td>\r\nPolysaccharides (starches)<\/td>\r\n\u03b1-Dextrins, disaccharides (maltose), trisaccharides (maltotriose)<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nPancreatic lipase<\/td>\r\nPancreatic acinar cells<\/td>\r\nTriglycerides that have been emulsified by bile salts<\/td>\r\nFatty acids and monoacylglycerides<\/td>\r\n<\/tr>\r\n
          Pancreatic enzymes<\/td>\r\nTrypsin*<\/td>\r\nPancreatic acinar cells<\/td>\r\nProteins<\/td>\r\nPeptides<\/td>\r\n<\/tr>\r\n
          Data source: (\"Chemical digestion and absorption,\" 2022)[footnote]Table modified from one accessed for free at: https:\/\/openstax.org\/books\/anatomy-and-physiology-2e\/pages\/23-7-chemical-digestion-and-absorption-a-closer-look<\/a>[\/footnote]<\/span><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n
          <\/div>\r\n
          *These enzymes have been activated by other substances.<\/span><\/div>\r\n
          <\/div>\r\n
          \r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
          Table<\/span> 3.4: Hormones involved in digestion<\/span><\/caption>\r\n
          Hormone<\/th>\r\nSite of Production<\/th>\r\nSite of Action<\/th>\r\nAction<\/th>\r\n<\/tr>\r\n<\/thead>\r\n
          Gastrin<\/td>\r\nStomach<\/td>\r\nStomach<\/td>\r\nStimulates secretion of HCl and pepsinogen and stimulates gastric motility\r\n\r\nPromotes gastric mucosal cell proliferation<\/td>\r\n<\/tr>\r\n
          Secretin<\/td>\r\nSmall intestine<\/td>\r\nPancreas\r\n\r\nStomach<\/td>\r\nStimulates secretion of bicarbonate\r\n\r\nDecreases gastric motility<\/td>\r\n<\/tr>\r\n
          Cholecystokinin (CCK)<\/td>\r\nSmall intestine<\/td>\r\nPancreas\r\n\r\nGall bladder\r\n\r\nStomach<\/td>\r\nStimulates\r\n\r\nStimulates gall bladder contraction\r\n\r\nSlows gastric emptying<\/td>\r\n<\/tr>\r\n
          Gastric inhibitory peptide<\/td>\r\nSmall intestine<\/td>\r\nStomach\r\n\r\nPancreas<\/td>\r\nInhibits gastric acid secretion\r\n\r\nSlows gastric emptying and stimulates insulin release<\/td>\r\n<\/tr>\r\n
          Data source: Thompson et al., 2014. [footnote]Thompson JL, Manore MM, Vaughan LA, Gottschall-Pass K, MacLellan DL. The Science of Nutrition. Canadian Edition. Likach N, Haggert C, Bhatt N, editors. Upper Saddle River, New Jersey, USA: Pearson Education Inc; 2014. [\/footnote]<\/span><\/span>\r\n\r\n <\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n
          <\/div>\r\n
          \r\n

          Everyday Connection<\/h3>\r\n\"\"\r\n\r\nThere has been significant talk about pre-and probiotic foods in the mainstream media. The World Health Organization defines probiotics as live bacteria that confer beneficial health effects on their host. They are sometimes called \u201cfriendly bacteria.\u201d The most common bacteria labeled as probiotic is lactic acid bacteria (lactobacilli). They are added as live cultures to certain fermented foods such as yogurt. Prebiotics are indigestible foods, primarily soluble fibers, that stimulate the growth of certain strains of bacteria in the large intestine and provide health benefits to the host. A review article in the June 2008 issue of the Journal of Nutrition concludes that there is scientific consensus that probiotics ward off viral-induced diarrhea and reduce the symptoms of lactose intolerance.[footnote]Farnworth ER. The Evidence to Support Health Claims for Probiotics. J Nutr. 2008; 138(6), 1250S\u20134S. http:\/\/jn.nutrition.org\/content\/138\/6\/1250S.long. Accessed September 22, 2017.[\/footnote]\r\n\r\nExpert nutritionists agree that more health benefits of pre-and probiotics will likely reach scientific consensus. As the fields of pre- and probiotic manufacturing and their clinical study progress, more information on proper dosing and what exact strains of bacteria are potentially \u201cfriendly\u201d will become available.\r\n\r\nYou may be interested in trying some of these foods in your diet. A simple food to try is Kefir. Several websites such as BBC Good Food<\/a> provide a list of tasty Kefir recipes you may be interested in trying. Kefir, a dairy product fermented with probiotic bacteria, can make a pleasant-tasting breakfast smoothie.\r\n\r\n \r\n
          \r\n
          \r\n
          \r\n
          \r\n
          \r\n
          Alternative sources of pre and probiotics have long been a part of indigenous diets and hold cultural significance. Fermented foods such as sauerkraut or kimchi are valued in many Indigenous cultures. These foods introduce beneficial bacteria into their diet.<\/div>\r\n<\/div>\r\n<\/div>\r\n
          \r\n
          <\/div>\r\n
          <\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n
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          <\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n ","rendered":"
          \n
          \n

          What Happens to the Food You Eat?<\/h3>\n<\/header>\n
          \n

          When you ingest food, a 3-part process takes place:<\/p>\n

            \n
          1. Digestion<\/strong>: The process of breaking down food into smaller molecules, which can occur mechanically or chemically.<\/li>\n
          2. Absorption<\/strong>: The process of taking these smaller molecules from the gastrointestinal tract through the intestinal wall and into the circulation (e.g., blood or lymph).<\/li>\n
          3. Elimination<\/strong>: The removal of undigested or unabsorbed food and waste products.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n

            Once you have eaten, your digestive system starts the process that breaks down the components of food into smaller components that can be absorbed and taken into the body. To do this, the digestive system functions on two levels, mechanically to move and mix ingested food, and chemically to break down large molecules. The smaller nutrient molecules can then be absorbed and processed by cells throughout the body for energy or used as building blocks for new cells.<\/p>\n

             <\/p>\n

            \"The
            Figure 3.2 Digestion Breakdown of Macronutrients.<\/figcaption><\/figure>\n

            Digestion converts components of the food we eat into smaller molecules that can be absorbed into the body and utilized for energy needs or as building blocks for making larger molecules in cells. Nutrients, as well as some non-nutrients, are absorbed. Anything that isn’t absorbed into the body, such as fibre, is excreted\/eliminated.<\/p>\n

            The Gastrointestinal (GI) tract<\/h1>\n

            The GI tract is a tube-like structure that starts at the mouth and ends at the anus, including everything in between.<\/p>\n

             <\/p>\n

            \"An
            Figure 3.3 The human digestive system.<\/figcaption><\/figure>\n

            There are several distinct sections of the GI tract that play a role in digestion, absorption, and elimination:<\/p>\n

              \n
            1. Mouth<\/li>\n
            2. Esophagus<\/li>\n
            3. Stomach<\/li>\n
            4. Small intestine<\/li>\n
            5. Large intestine<\/li>\n<\/ol>\n

              Movement between these sections is controlled by sphincters, which are rings of muscle that respond to nerve signals, causing them to open or close. Smooth muscle tissue surrounds the GI tract and its contraction produces waves, known as peristalsis or haustration, that propel food through the tract.<\/p>\n

              Several accessory organs also play a role in the digestion and absorption of nutrients:<\/p>\n

                \n
              1. Salivary glands<\/li>\n
              2. Liver<\/li>\n
              3. Pancreas<\/li>\n
              4. Gall bladder<\/li>\n<\/ol>\n

                The GI tract is lined with mucosal tissue that secretes digestive juices (which aid in the breakdown of food) and mucus (which facilitates the propulsion of food through the tract).<\/p>\n

                From the Brain to the Stomach<\/h1>\n

                The Cephalic Phase of Digestion<\/h2>\n

                The process of digestion begins even before you put food into your mouth. The cephalic phase<\/strong> of digestion begins when you start thinking about food. When you feel hungry, your body sends a message to your brain that it is time to eat. Sights and smells influence your body\u2019s preparedness for food. Smelling food sends a message to your brain. Your brain then tells the mouth to get ready, you start salivating, and your stomach starts secreting gastric juices in preparation for your meal. Specifically, the cells lining the stomach will secrete the hormone gastrin, which stimulates the gastric glands to secrete digestive juices.<\/p>\n

                The Mouth<\/h2>\n

                In the mouth, where the second step of digestion starts, the mechanical and chemical breakdown of food begins. The chemical breakdown of food involves enzymes such as salivary amylase, which starts the breakdown of large starch molecules into smaller components. Lingual lipase, produce in the mouth, helps to initiate the breakdown of lipids. Some lipid breakdown occurs in the mouth, but more occurs in the stomach as the enzyme operates optimally in the acidic stomach environment.<\/p>\n

                Mechanical breakdown starts with mastication (chewing) in the mouth, which moistens the food, increases its surface area, mixes it together, and stimulates the production of saliva. Saliva provides lubrication and enables food movement downward. The slippery mass of partially broken-down food is called a bolus, which moves down the digestive tract as you swallow. Swallowing may seem voluntary at first because it requires conscious effort to push the food with the tongue back toward the throat, but after this, swallowing proceeds involuntarily, meaning it cannot be stopped once it begins. As you swallow, the bolus is pushed from the mouth through the pharynx and into a muscular tube called the esophagus. As the bolus travels through the pharynx, a small flap called the epiglottis closes to prevent choking by keeping food from going into the trachea.<\/p>\n

                \n
                \n

                Digestive Enzymes<\/h3>\n<\/header>\n
                \n

                Enzymes play a key role in chemical digestion.<\/p>\n

                  \n
                1. Amylases<\/strong> break down carbohydrates<\/strong><\/li>\n
                2. Lipases<\/strong> break down lipids<\/strong><\/li>\n
                3. Proteases<\/strong> break down proteins<\/strong><\/li>\n<\/ol>\n<\/div>\n<\/div>\n

                  The Esophagus<\/h2>\n

                  In addition to the epiglottis closing, the upper esophageal sphincter (a sphincter at the top of the esophagus; Figure 3.4 “The trachea, the esophagus and its associated sphincters”) needs to open, to allow the bolus to enter the esophagus. The esophagus is a muscular tube connecting the pharynx (throat) to the stomach and transports the bolus of food between these two sections. In an action known as peristalsis<\/strong><\/em>, the muscles of the esophagus contract to squeeze and push the food bolus down to the stomach (Figure 3.5 “Peristalsis in the esophagus”).<\/p>\n

                   <\/p>\n

                  \"The
                  Figure 3.4 The trachea, the esophagus and its associated sphincters.<\/figcaption><\/figure>\n

                   <\/p>\n

                  \"Peristalsis\"
                  Figure 3.5 Peristalsis in the esophagus.<\/figcaption><\/figure>\n

                  The Stomach<\/h2>\n

                  At the junction between the esophagus and stomach, there is a sphincter muscle, known as the gastroesophageal\u00a0 (or lower esophageal or cardiac) sphincter (Figure 3.4) that remains closed until the food bolus approaches. The pressure of the food bolus stimulates the lower esophageal sphincter to relax and open, allowing the food to move from the esophagus into the stomach. Solid food takes between four and eight seconds to travel down the esophagus, and liquids take about one second. When food enters the stomach, a highly muscular organ, powerful peristaltic contractions help mash, pulverize, and churn food into chyme, which is a semiliquid mass of partially digested food that also contains gastric juices. Even before the food arrives at the stomach, the cells lining the stomach will secrete the hormone gastrin, which stimulates the gastric glands to secrete digestive juices. Gastric glands contain two cell types, parietal cells and chief cells, that produce the components of gastric juice listed below:<\/p>\n\n\n\n\n\n
                  Table 3.1: The components of gastric juice, produced by the parietal and chief cells<\/caption>\n
                  Parietal Cells<\/strong><\/td>\nChief Cells<\/strong><\/td>\n<\/tr>\n
                  Hydrochloric acid: important for protein denaturation, killing bacteria\/ germs, and activating pepsinogen into pepsin<\/td>\nSecrete pepsinogen, pepsinogen is then converted to pepsin by hydrochloric acid, which is important for protein digestion.<\/td>\n<\/tr>\n
                  Intrinsic factor: important for vitamin B12<\/sub> absorption<\/td>\nGastric lipase: important for lipid digestion<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

                  The length of time food spends in the stomach varies by the macronutrient composition of the meal. A high-fat or high-protein meal takes longer to break down than one rich in carbohydrates. It usually takes a few hours after a meal to empty the stomach contents completely into the small intestine. Minimal amounts of water, minerals, and drugs are absorbed in the stomach as the majority of absorption takes place in the small intestine.<\/p>\n

                  \n
                  \n

                  If the stomach contains acid, why doesn’t the stomach lining always erode?<\/h3>\n<\/header>\n
                  \u00a0The stomach contains cells that secrete bicarbonate and mucus to help neutralize acid near the surface of the stomach lining and provide a protective layer against hydrochloric acid.<\/div>\n<\/div>\n
                  \n

                  Gastrointestinal Disorders: Heartburn and Gastroesophageal reflux disease (GERD)<\/span><\/p>\n

                  When the gastroesophageal sphincter remains partially opened, this may cause gastric juice, which contains hydrochloric acid, to seep back into the esophagus. This can result in feelings of heartburn, or if it is more painful, frequent, and persistent, it can be classified as GERD. To try and reduce GERD, people are advised to identify triggers and avoid them, eat smaller meals, wait for a few hours before lying down (and consider raising their head), or take medications (e.g., antacids or proton pump inhibitors). If left untreated, scar tissue can develop in the esophagus, making it hard to swallow and even aggravating asthma.<\/p>\n<\/div>\n

                  The Small Intestine and the Accessory Organs<\/h1>\n

                  From the stomach, chyme passes into the small intestine with the pyloric sphincter separating these two sections (Figure 3.6). The small intestine is divided into three structural parts: the duodenum, the jejunum, and the ileum (Figure 3.7).<\/p>\n

                   <\/p>\n

                  \"The
                  Figure 3.6 The stomach and the small intestine.<\/figcaption><\/figure>\n

                   <\/p>\n

                  \"The
                  Figure 3.7 Sections of the small intestine.<\/figcaption><\/figure>\n

                  The Accessory Organs: The Liver, Pancreas and Gall Bladder<\/h1>\n

                  Chemical digestion in the small intestine relies on 3 key accessory organs: the liver, gall bladder and pancreas. Once the chyme enters the duodenum (the first segment of the small intestine), this signals the release of secretin; the presence of protein and fat in the duodenum also signals the release of cholecystokinin (CCK)\u00a0 into the duodenum. This in turn signals the pancreas and gallbladder to release juices that assist in digestion.<\/span><\/p>\n

                  Specifically, following CCK secretion, \u00a0the gallbladder secretes bile (which is made in the liver but stored in the gall bladder), into the duodenum of the small intestine via the common bile duct (Figure 3.8).\u00a0 Bile\u2019s components emulsify fats and break them down into smaller droplets; it acts similar to how dish soap removes grease from a frying pan. This allows for the movement of fats in the watery environment of the small intestine.<\/p>\n

                   <\/p>\n

                  \"The
                  Figure 3.8 The gallbladder.<\/figcaption><\/figure>\n
                  <\/div>\n

                  Additionally, following CCK secretion, the pancreas secretes pancreatic juices into the duodenum of the small intestine, via the pancreatic duct (Figure 3.9). This fluid consists mostly of water, but it also contains enzymes that further break down proteins (e.g., proteases), carbohydrates (e.g., pancreatic amylase), and lipids (e.g., pancreatic lipase). The pancreatic juices also contain bicarbonate ions that neutralize the acidity of the stomach-derived chyme, which helps the pancreatic enzymes work more effectively. Additionally, the pancreas produces insulin and glucagon which play a key role in blood glucose maintenance.<\/p>\n

                   <\/p>\n

                  \"The
                  Figure 3.9 The pancreas.<\/figcaption><\/figure>\n

                  Nutrient Absorption<\/h1>\n

                  When the digestive system has broken down food into its nutrient components, the body eagerly awaits delivery; for this to happen, the nutrients must be absorbed from the GI tract into the blood or lymph. The small intestine is the site of the most nutrient absorption. The heavily folded nature of this lining creates a large surface area to maximize nutrient absorption. The surface area is increased by folds, villi, and microvilli. Digested nutrients are absorbed into either capillaries or lymphatic vessels contained within each microvillus. Its surface area is greater than 200 square meters, which is about the size of a tennis court. The large surface area is due to the multiple levels of folding. The internal tissue of the small intestine is covered in villi, which are tiny finger-like projections that are covered with even smaller projections, called microvilli (Figure 3.10 \u201cStructure of the small intestine”).<\/p>\n

                  The digested nutrients pass through the absorptive cells of the intestine via passive diffusion, facilitated diffusion or active transport. Water-soluble nutrients such as amino acids, short fatty acids, and monosaccharides (sugars) are transported from the intestinal cells into capillaries and then transported to the liver via the portal vein. Larger fatty acids, fat-soluble vitamins, and other lipids are transported by a more circuitous route through the lymphatic vessels, which eventually meet up with blood vessels. The lymphatic system is a one-way system of vessels that transports lymph, a fluid rich in white blood cells, and lipid-soluble substances after a meal containing lipids. The lymphatic system slowly moves its contents through the lymphatic vessels and empties into blood vessels in the upper chest area. Now, the absorbed lipid-soluble components are in the blood where they can be distributed throughout the body and utilized by cells (see Figure 3.11 “The absorption of nutrients”).<\/p>\n

                   <\/p>\n

                  \"The
                  Figure 3.10 Structure of the small intestine.<\/figcaption><\/figure>\n

                   <\/p>\n

                  \"The
                  Figure 3.11 The absorption of nutrients.<\/figcaption><\/figure>\n
                  Gastrointestinal Disorders: Ulcers and Celiac Disease<\/span><\/div>\n
                  Ulcers
                  \n<\/span>Areas of the GI tract can become eroded by hydrochloric acid and pepsin, which can result in an ulcer. Gastric ulcers are found in the stomach and duodenal ulcers can be found in the duodenum. When someone has an ulcer, they may experience burning pain 1-3 hours after eating, vomit blood, or have bloody stool. The helicobacter pylori bacteria <\/span>plays a key role in the development of ulcers and it is thought that this bacteria burrows through the layers of mucus to expose the underlying sensitive layers of tissue. Some ulcers may be caused by the prolonged use of non-steroidal anti-inflammatory drugs.
                  \n<\/span><\/div>\n
                  Celiac Disease
                  \n<\/span>When someone with celiac disease ingests gluten, a protein found in wheat, barley, and rye, it causes an immune reaction, which, over time can damage the villi of the small intestine. As the small intestine is the major site of nutrient absorption, this can result in the malabsorption of nutrients. Symptoms of celiac disease may include bloating, gas, chronic diarrhea, lactose intolerance, nausea, vomiting, abdominal pain, or loose, greasy, bulk stool
                  \n[1]<\/sup><\/a>.<\/span><\/div>\n

                  Movement through the Small Intestine<\/h1>\n

                  Two different types of muscular contractions, called peristalsis and segmentation, control the movement and mixing of food in the small intestine. Similar to what occurs in the esophagus and stomach, peristalsis is circular waves of smooth muscle contraction that propel food forward. Segmentation from circular muscle contraction slows movement in the small intestine by forming temporary \u201csausage link\u201d type of segments that allow chyme to slosh food back and forth in both directions to promote mixing of the chyme and enhance absorption of nutrients (Figure 3.12 “Segmentation”). Almost all the components of food are completely broken down to their simplest units within the first 25 centimeters of the small intestine. Instead of proteins, carbohydrates, and lipids, the chyme now consists of amino acids, monosaccharides, and emulsified components of triglycerides.<\/p>\n

                   <\/p>\n

                  \"Segmentation\"
                  Figure 3.12 Segmentation<\/figcaption><\/figure>\n

                  From the Small Intestine to the Large Intestine<\/h1>\n

                  The process of digestion is fairly efficient. Any food that is still incompletely broken down (usually less than ten percent of food consumed) and the food\u2019s indigestible fibre content move from the small intestine to the large intestine (colon) through the ileocecal valve. The main task of the large intestine is to absorb much of the remaining water. Remember, water is present not only in solid foods and beverages, but the stomach also releases a few hundred milliliters of gastric juice, and the pancreas adds approximately 500 milliliters during the digestion of the meal. For the body to conserve water, excessive amounts of water mustn’t be lost in fecal matter. In the large intestine, no further chemical or mechanical breakdown of food takes place unless it is accomplished by the bacteria that inhabit this portion of the intestinal tract. The number of bacteria residing in the large intestine is estimated to be greater than 1014, which is more than the total number of cells in the human body (1013). This may seem rather unpleasant, but the great majority of bacteria in the large intestine are harmless and many are even beneficial.<\/p>\n

                   <\/p>\n

                   <\/p>\n

                  \"The
                  Figure 3.12 Sections of the large intestine.<\/figcaption><\/figure>\n

                  From the Large Intestine to the Anus<\/h1>\n

                  After a few hours in the stomach, plus three to six hours in the small intestine, and about sixteen hours in the large intestine, the digestion process enters step four, which is the elimination of indigestible food matter as feces. Feces contain indigestible food components and gut bacteria (which comprise almost 50 percent of the content). It is stored in the rectum until it is expelled through the anus via defecation.<\/p>\n

                  Summary of the Functions of the Digestive Organs<\/h1>\n\n\n\n\n\n\n\n\n\n\n\n\n
                  Table 3.2: Summary of the functions of the digestive organs\u00a0<\/span><\/caption>\n
                  Organ<\/th>\nMajor functions<\/th>\nOther functions<\/th>\n<\/tr>\n<\/thead>\n
                  Mouth<\/td>\n\n
                    \n
                  • Ingests food<\/li>\n
                  • Chews and mixes food<\/li>\n
                  • Begins chemical breakdown of carbohydrates<\/li>\n
                  • Moves food into the pharynx<\/li>\n
                  • Produces lingual lipase<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Moistens and dissolves food, allowing you to taste it<\/li>\n
                  • Cleans and lubricates the teeth and oral cavity<\/li>\n
                  • Has some antimicrobial activity<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Pharynx<\/td>\n\n
                    \n
                  • Propels food from the oral cavity to the esophagus<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Lubricates food and passageways<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Esophagus<\/td>\n\n
                    \n
                  • Propels food to the stomach<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Lubricates food and passageways<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Stomach<\/td>\n\n
                    \n
                  • Mixes and churns food with gastric juices to form chyme<\/li>\n
                  • Begins chemical breakdown of proteins and some fats<\/li>\n
                  • Releases food into the duodenum as chyme<\/li>\n
                  • Absorbs some fat-soluble substances (for example, alcohol, aspirin)<\/li>\n
                  • Possesses antimicrobial functions<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Stimulates protein-digesting enzymes<\/li>\n
                  • Secretes intrinsic factor required for vitamin B12<\/sub> absorption in the small intestine<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Small intestine<\/td>\n\n
                    \n
                  • Mixes chyme with digestive juices<\/li>\n
                  • Propels food at a rate slow enough for digestion and absorption<\/li>\n
                  • Absorbs breakdown products of carbohydrates, proteins, lipids, and nucleic acids, along with vitamins, minerals, and water<\/li>\n
                  • Performs physical digestion via segmentation<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Provides an optimal medium for enzymatic activity<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Accessory organs<\/td>\n\n
                    \n
                  • Liver: produces bile salts, which emulsify lipids, aiding their digestion and absorption<\/li>\n
                  • Gallbladder: stores, concentrates, and releases bile<\/li>\n
                  • Pancreas: produces digestive enzymes and bicarbonate<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Bicarbonate-rich pancreatic juices help neutralize acidic chyme and provide the optimal environment for enzymatic activity<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Large intestine<\/td>\n\n
                    \n
                  • Further breaks down food residues<\/li>\n
                  • Absorbs most residual water, electrolytes, and vitamins produced by enteric bacteria<\/li>\n
                  • Propels feces toward the rectum<\/li>\n
                  • Eliminates feces<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Food residue is concentrated and temporarily stored prior to defecation<\/li>\n
                  • Mucus eases the passage of feces through the colon<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Data source: (“Digestive system processes and regulation,” 2022)[2]<\/sup><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

                   <\/p>\n

                  Summary of Enzymes and Hormones Involved in Digestion<\/h1>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
                  Table<\/span> 3.3:\u00a0Enzymes involved in digestion <\/span><\/caption>\n
                  Category<\/th>\nEnzyme Name<\/th>\nSource<\/th>\nSubstrate<\/th>\nProduct<\/th>\n<\/tr>\n<\/thead>\n
                  Salivary Enzymes<\/td>\nLingual lipase<\/td>\nLingual glands<\/td>\nTriglycerides<\/td>\nFree fatty acids, and mono- and diglycerides<\/td>\n<\/tr>\n
                  Salivary Enzymes<\/td>\nSalivary amylase<\/td>\nSalivary glands<\/td>\nPolysaccharides<\/td>\nDisaccharides and trisaccharides<\/td>\n<\/tr>\n
                  Gastric enzymes<\/td>\nGastric lipase<\/td>\nChief cells<\/td>\nTriglycerides<\/td>\nFatty acids and monoacylglycerides<\/td>\n<\/tr>\n
                  Gastric enzymes<\/td>\nPepsin*<\/td>\nChief cells<\/td>\nProteins<\/td>\nPeptides<\/td>\n<\/tr>\n
                  Brush border enzymes<\/td>\nLactase<\/td>\nSmall intestine<\/td>\nLactose<\/td>\nGlucose and galactose<\/td>\n<\/tr>\n
                  Brush border enzymes<\/td>\nMaltase<\/td>\nSmall intestine<\/td>\nMaltose<\/td>\nGlucose<\/td>\n<\/tr>\n
                  Brush border enzymes<\/td>\nSucrase<\/td>\nSmall intestine<\/td>\nSucrose<\/td>\nGlucose and fructose<\/td>\n<\/tr>\n
                  Brush border enzymes<\/td>\nPeptidases<\/td>\nSmall intestine<\/td>\n\n
                    \n
                  • Aminopeptidase: amino acids at the amino end of peptides<\/li>\n
                  • Dipeptidase: dipeptides<\/li>\n<\/ul>\n<\/td>\n
                  		\n
                    \n
                  • Aminopeptidase: amino acids and peptides<\/li>\n
                  • Dipeptidase: amino acids<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nCarboxy-peptidase*<\/td>\nPancreatic acinar cells<\/td>\nAmino acids at the carboxyl end of peptides<\/td>\nAmino acids and peptides<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nChymotrypsin*<\/td>\nPancreatic acinar cells<\/td>\nProteins<\/td>\nPeptides<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nElastase*<\/td>\nPancreatic acinar cells<\/td>\nProteins<\/td>\nPeptides<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nNucleases<\/td>\nPancreatic acinar cells<\/td>\n\n
                    \n
                  • Ribonuclease: ribonucleic acids<\/li>\n
                  • Deoxyribonuclease: deoxyribonucleic acids<\/li>\n<\/ul>\n<\/td>\n
                  		Nucleotides<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nPancreatic amylase<\/td>\nPancreatic acinar cells<\/td>\nPolysaccharides (starches)<\/td>\n\u03b1-Dextrins, disaccharides (maltose), trisaccharides (maltotriose)<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nPancreatic lipase<\/td>\nPancreatic acinar cells<\/td>\nTriglycerides that have been emulsified by bile salts<\/td>\nFatty acids and monoacylglycerides<\/td>\n<\/tr>\n
                  Pancreatic enzymes<\/td>\nTrypsin*<\/td>\nPancreatic acinar cells<\/td>\nProteins<\/td>\nPeptides<\/td>\n<\/tr>\n
                  Data source: (“Chemical digestion and absorption,” 2022)[3]<\/sup><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
                  <\/div>\n
                  *These enzymes have been activated by other substances.<\/span><\/div>\n
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                  Table<\/span> 3.4: Hormones involved in digestion<\/span><\/caption>\n
                  Hormone<\/th>\nSite of Production<\/th>\nSite of Action<\/th>\nAction<\/th>\n<\/tr>\n<\/thead>\n
                  Gastrin<\/td>\nStomach<\/td>\nStomach<\/td>\nStimulates secretion of HCl and pepsinogen and stimulates gastric motility<\/p>\n

                  Promotes gastric mucosal cell proliferation<\/td>\n<\/tr>\n

                  Secretin<\/td>\nSmall intestine<\/td>\nPancreas<\/p>\n

                  Stomach<\/td>\n

                  		Stimulates secretion of bicarbonate<\/p>\n

                  Decreases gastric motility<\/td>\n<\/tr>\n

                  Cholecystokinin (CCK)<\/td>\nSmall intestine<\/td>\nPancreas<\/p>\n

                  Gall bladder<\/p>\n

                  Stomach<\/td>\n

                  		Stimulates<\/p>\n

                  Stimulates gall bladder contraction<\/p>\n

                  Slows gastric emptying<\/td>\n<\/tr>\n

                  Gastric inhibitory peptide<\/td>\nSmall intestine<\/td>\nStomach<\/p>\n

                  Pancreas<\/td>\n

                  		Inhibits gastric acid secretion<\/p>\n

                  Slows gastric emptying and stimulates insulin release<\/td>\n<\/tr>\n

                  Data source: Thompson et al., 2014. [4]<\/sup><\/a><\/span><\/span><\/p>\n

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                  Everyday Connection<\/h3>\n

                  \"\"<\/p>\n

                  There has been significant talk about pre-and probiotic foods in the mainstream media. The World Health Organization defines probiotics as live bacteria that confer beneficial health effects on their host. They are sometimes called \u201cfriendly bacteria.\u201d The most common bacteria labeled as probiotic is lactic acid bacteria (lactobacilli). They are added as live cultures to certain fermented foods such as yogurt. Prebiotics are indigestible foods, primarily soluble fibers, that stimulate the growth of certain strains of bacteria in the large intestine and provide health benefits to the host. A review article in the June 2008 issue of the Journal of Nutrition concludes that there is scientific consensus that probiotics ward off viral-induced diarrhea and reduce the symptoms of lactose intolerance.[5]<\/sup><\/a><\/p>\n

                  Expert nutritionists agree that more health benefits of pre-and probiotics will likely reach scientific consensus. As the fields of pre- and probiotic manufacturing and their clinical study progress, more information on proper dosing and what exact strains of bacteria are potentially \u201cfriendly\u201d will become available.<\/p>\n

                  You may be interested in trying some of these foods in your diet. A simple food to try is Kefir. Several websites such as BBC Good Food<\/a> provide a list of tasty Kefir recipes you may be interested in trying. Kefir, a dairy product fermented with probiotic bacteria, can make a pleasant-tasting breakfast smoothie.<\/p>\n

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                  Alternative sources of pre and probiotics have long been a part of indigenous diets and hold cultural significance. Fermented foods such as sauerkraut or kimchi are valued in many Indigenous cultures. These foods introduce beneficial bacteria into their diet.<\/div>\n<\/div>\n<\/div>\n
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                  Media Attributions<\/h2>