{"id":277,"date":"2019-12-08T22:34:10","date_gmt":"2019-12-09T03:34:10","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/nursingpharmacology\/chapter\/6-11-antilipemics\/"},"modified":"2022-01-14T20:31:54","modified_gmt":"2022-01-15T01:31:54","slug":"6-11-antilipemics","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/nursingpharmacology\/chapter\/6-11-antilipemics\/","title":{"raw":"6.11 Antilipemics","rendered":"6.11 Antilipemics"},"content":{"raw":"

Antilipemic Medications<\/h3>\r\nAntilipemic agents reduce hyperlipidemia that may lead to additional health problems such as stroke, myocardial infarction, angina, and heart failure. Medications should be used in adjunct with a healthy diet and exercise regime approved by the client\u2019s health care provider.\r\n

<\/a>Ezetimibe<\/h3>\r\nMechanism of Action<\/strong>\r\n\r\nEzetimibe blocks the absorption of cholesterol in the small intestines to reduce LDL.\r\n\r\nIndications for Use<\/strong>\r\n\r\nThis medication is used for treatment of hyperlipidemia and familial hypercholesterolemia.\r\n\r\nNursing Considerations Across the Lifespan<\/strong>\r\n\r\nIf medication is combined with HMG-CoA reductase inhibitors, do not give to pregnant or breastfeeding clients.\r\n\r\nAdverse\/Side Effects<\/strong>\r\n\r\nUse with caution when ezetimibe is combined with additional medication. Clients may experience arthralgia, rhabdomyolysis, hepatic impairment, dizziness, upper respiratory infections, or diarrhea if they are taking this medication. Minimal side effects were reported with monotherapy.[footnote] This work is a derivative of Daily Med<\/a> by U.S. National Library of Medicine<\/a> in the public domain<\/a>. [\/footnote]<\/sup>\r\n\r\nClient Teaching & Education<\/strong>\r\n\r\nClients should take the prescribed medication as directed and avoid consuming grapefruit juice during drug therapy.\u00a0 The medication should be used with dietary modifications.\u00a0 If the client experiences muscle pain, tenderness, or weakness, this should be reported to the healthcare provider.[footnote]uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a>[\/footnote]<\/sup>\r\n

<\/a>Atorvastatin<\/h3>\r\nMechanism of Action<\/strong>\r\n\r\nAtorvastatin inhibits HMG-CoA reductase and cholesterol synthesis, which reduces LDL (low density lipoprotein).\r\n\r\nIndications for Use<\/strong>\r\n\r\nThis medication is used for hyperlipidemia and the prevention of cardiovascular disease.\r\n\r\nNursing Considerations Across the Lifespan<\/strong>\r\n\r\nDo not use with clients who have hepatic disease.\r\n\r\nThis medication is contraindicated with clients who are pregnant or breastfeeding. Do not give to clients under 10 years of age.\r\n\r\nUse caution with geriatric clients due to increased risk for myopathy.\r\n\r\nAdverse\/Side Effects<\/strong>\r\n\r\nClients who are pregnant or breastfeeding should not take this medication. A health care provider will assess routine liver function for a client taking atorvastatin. Nausea, diarrhea, dyspepsia, increase in blood glucose, rhabdomyolysis, myalgia, or muscle spasms may be produced by taking this medication. Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly, causing muscle pain and weakness. Some of the muscle breakdown products are harmful to the kidneys and can cause kidney failure. There may be tea-colored urine or an irregular heartbeat with rhabdomyolysis. [footnote]This work is a derivative of Daily Med<\/a> by U.S. National Library of Medicine<\/a> in the public domain<\/a>. [\/footnote]<\/sup>\r\n\r\nClient Teaching & Education<\/strong>\r\n\r\nClients should take the prescribed medication as directed and avoid consuming grapefruit juice during drug therapy.\u00a0 The medication should be used with dietary modifications.\u00a0 If the client experiences muscle pain, tenderness, or weakness, these should be reported to the healthcare provider.[footnote]uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a>[\/footnote]<\/sup>\r\n\r\nNow let's take a closer look at the medication grid on atorvastatin in Table 6.11.[footnote]This work is a derivative of Daily Med<\/a> by U.S. National Library of Medicine<\/a> in the public domain<\/a>. [\/footnote]<\/sup>\r\n\r\n\"\"","rendered":"

Antilipemic Medications<\/h3>\n

Antilipemic agents reduce hyperlipidemia that may lead to additional health problems such as stroke, myocardial infarction, angina, and heart failure. Medications should be used in adjunct with a healthy diet and exercise regime approved by the client\u2019s health care provider.<\/p>\n

<\/a>Ezetimibe<\/h3>\n

Mechanism of Action<\/strong><\/p>\n

Ezetimibe blocks the absorption of cholesterol in the small intestines to reduce LDL.<\/p>\n

Indications for Use<\/strong><\/p>\n

This medication is used for treatment of hyperlipidemia and familial hypercholesterolemia.<\/p>\n

Nursing Considerations Across the Lifespan<\/strong><\/p>\n

If medication is combined with HMG-CoA reductase inhibitors, do not give to pregnant or breastfeeding clients.<\/p>\n

Adverse\/Side Effects<\/strong><\/p>\n

Use with caution when ezetimibe is combined with additional medication. Clients may experience arthralgia, rhabdomyolysis, hepatic impairment, dizziness, upper respiratory infections, or diarrhea if they are taking this medication. Minimal side effects were reported with monotherapy.[1]<\/sup><\/a><\/sup><\/p>\n

Client Teaching & Education<\/strong><\/p>\n

Clients should take the prescribed medication as directed and avoid consuming grapefruit juice during drug therapy.\u00a0 The medication should be used with dietary modifications.\u00a0 If the client experiences muscle pain, tenderness, or weakness, this should be reported to the healthcare provider.[2]<\/sup><\/a><\/sup><\/p>\n

<\/a>Atorvastatin<\/h3>\n

Mechanism of Action<\/strong><\/p>\n

Atorvastatin inhibits HMG-CoA reductase and cholesterol synthesis, which reduces LDL (low density lipoprotein).<\/p>\n

Indications for Use<\/strong><\/p>\n

This medication is used for hyperlipidemia and the prevention of cardiovascular disease.<\/p>\n

Nursing Considerations Across the Lifespan<\/strong><\/p>\n

Do not use with clients who have hepatic disease.<\/p>\n

This medication is contraindicated with clients who are pregnant or breastfeeding. Do not give to clients under 10 years of age.<\/p>\n

Use caution with geriatric clients due to increased risk for myopathy.<\/p>\n

Adverse\/Side Effects<\/strong><\/p>\n

Clients who are pregnant or breastfeeding should not take this medication. A health care provider will assess routine liver function for a client taking atorvastatin. Nausea, diarrhea, dyspepsia, increase in blood glucose, rhabdomyolysis, myalgia, or muscle spasms may be produced by taking this medication. Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly, causing muscle pain and weakness. Some of the muscle breakdown products are harmful to the kidneys and can cause kidney failure. There may be tea-colored urine or an irregular heartbeat with rhabdomyolysis. [3]<\/sup><\/a><\/sup><\/p>\n

Client Teaching & Education<\/strong><\/p>\n

Clients should take the prescribed medication as directed and avoid consuming grapefruit juice during drug therapy.\u00a0 The medication should be used with dietary modifications.\u00a0 If the client experiences muscle pain, tenderness, or weakness, these should be reported to the healthcare provider.[4]<\/sup><\/a><\/sup><\/p>\n

Now let’s take a closer look at the medication grid on atorvastatin in Table 6.11.[5]<\/sup><\/a><\/sup><\/p>\n

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Media Attributions<\/h2>