{"id":1447,"date":"2021-08-25T00:44:02","date_gmt":"2021-08-25T04:44:02","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/pathology\/?post_type=chapter&p=1447"},"modified":"2025-01-29T17:04:38","modified_gmt":"2025-01-29T22:04:38","slug":"pre-test-for-metastatic-melanoma","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/pathology\/chapter\/pre-test-for-metastatic-melanoma\/","title":{"raw":"Pre-Test for Metastatic Melanoma","rendered":"Pre-Test for Metastatic Melanoma"},"content":{"raw":"

Normal skin anatomy & histology<\/h2>\r\n
[h5p id=\"6\"]<\/div>\r\n
\r\n\r\n1. This protects skin cells from the damaging UV rays.<\/strong>\r\n
    \r\n \t
  • Melanocytes<\/li>\r\n \t
  • Keratin<\/li>\r\n \t
  • Sweat produced by sweat glands<\/li>\r\n \t
  • Hair<\/li>\r\n \t
  • Blood vessels<\/li>\r\n<\/ul>\r\n2. The junction between the hypodermis and underlying muscle is the basement membrane of the epidermis (skin).<\/strong>\r\n
      \r\n \t
    • True<\/li>\r\n \t
    • False<\/li>\r\n<\/ul>\r\n3. Fill in the blanks with the following words:\r\n<\/strong>\r\n\r\nmelanocytes, keratin, epidermis, melanin cells, hypodermis, cells, dead living keratinocyte, dermis\r\n\r\nThe skin is divided into the very thin, outermost _____, the slightly thicker _____ and the fatty _____. The predominant cell in the epidermis is the _____ which is responsible for making the tough protective protein _____. The outermost layer is made entirely out of _____. To protect the _____, _____ make the protein _____ which act as a pigment to 'shade' the UV rays of sun.\r\n\r\n4. <\/strong>Place the following terms on the histology diagram:<\/strong> <\/span><\/span>\r\n\r\nepidermis (dead layer), epidermis (alive layer), dermis.<\/span><\/span>\r\n\r\n\"\"\r\n\r\n \r\n\r\n5. Fill in the blank.<\/strong>\r\n\r\nA 3mm mole on the arm has an increased number of _____ compared to the surrounding skin. This is evident due to the mole's increased pigmentation which vary from brown to black.\r\n\r\n<\/div>\r\n

      Metastatic melanoma<\/h2>\r\n
      [h5p id=\"16\"]<\/div>\r\n
      \r\n\r\n1. Damage to DNA leading to melanoma occurs after the age of 50 years old.<\/strong>\r\n
        \r\n \t
      • True<\/li>\r\n \t
      • False<\/li>\r\n<\/ul>\r\n2. Finish the following sentence. Cancer is uncontrolled growth of cells due to:\r\n<\/strong>\r\n\r\nSelect all that apply.<\/strong>\r\n
          \r\n \t
        • A loss of function of the genes responsible for tumour suppression<\/li>\r\n \t
        • A loss of function of the genes responsible for cell division<\/li>\r\n \t
        • An increase in function of the genes responsible for tumour suppression<\/li>\r\n \t
        • An increase of function of the genes responsible for cell division<\/li>\r\n<\/ul>\r\n3. Finish the following sentence. A likely site for metastasis from a melanoma that originates in the skin is:<\/strong>\r\n
            \r\n \t
          • Liver<\/li>\r\n \t
          • Nails<\/li>\r\n \t
          • Heart<\/li>\r\n \t
          • Tongue<\/li>\r\n \t
          • Hair<\/li>\r\n<\/ul>\r\n
            \r\n

            Answer Key<\/h2>\r\n

            Normal Skin Anatomy & Histology<\/h3>\r\n1. Melanocytes\r\n\r\n2. False\r\n\r\n3. Epidermis, dermis, hypodermis, keratinocyte, keratin, dead cells, living cells, melanocytes, melanin\r\n\r\n4.\u00a0 1. Dermis, 2. Epidermis (alive layer), 3. Epidermis (dead layer)\r\n\r\n5. Melanocytes\r\n

            Metastatic Melanoma<\/h3>\r\n1. False\r\n\r\n2. A loss of function of the genes responsible for tumour suppression, an increase of function of the genes responsible for cell division\r\n\r\n3. Liver\r\n\r\n<\/div>\r\n<\/div>\r\n ","rendered":"

            Normal skin anatomy & histology<\/h2>\n
            \n
            \n