{"id":7643,"date":"2024-12-05T16:17:26","date_gmt":"2024-12-05T21:17:26","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/pathology\/chapter\/circulation-and-the-cns-copied-but-not-cloned-from-gj-betts\/"},"modified":"2025-08-18T14:10:16","modified_gmt":"2025-08-18T18:10:16","slug":"circulation-and-the-cns-copied-but-not-cloned-from-gj-betts","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/pathology\/chapter\/circulation-and-the-cns-copied-but-not-cloned-from-gj-betts\/","title":{"raw":"Circulation and the CNS","rendered":"Circulation and the CNS"},"content":{"raw":"<div id=\"1\" class=\"ui-has-child-title\" data-type=\"abstract\"><section>\r\n<div class=\"textbox textbox--learning-objectives\"><header class=\"textbox__header\">\r\n<p class=\"textbox__title\">Learning Objectives<\/p>\r\n\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<p id=\"para-00001\">By the end of this section, you will be able to:<\/p>\r\n\r\n<ul id=\"list-00001\">\r\n \t<li>Describe the vessels that supply the CNS with blood.<\/li>\r\n \t<li>Name the components of the ventricular system and the regions of the brain in which each is located.<\/li>\r\n \t<li>Explain the production of cerebrospinal fluid and its flow through the ventricles.<\/li>\r\n \t<li>Explain how a disruption in circulation would result in a stroke.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<span style=\"text-align: initial;font-size: 1em\">The CNS is crucial to the operation of the body, and any compromise to the blood flow to the brain and spinal cord can lead to severe difficulties. The CNS has a privileged blood supply, meaning that the entry and exit of substances in the brain is tightly regulated. This is accomplished by a structure known as the blood-brain barrier (BBB). <\/span><span style=\"text-align: initial;font-size: 1em;color: #ff0000\"><span style=\"color: #000000\">Very little can pass through by diffusion. Most substances that cross the wall of a blood vessel into the CNS must do so through an active transport process. Because of this, only specific types of molecules can enter the CNS. Glucose\u2014the primary energy source\u2014is allowed, as are amino acids. Water and some other small particles, like gases and ions, can enter. But most everything else cannot, including white blood cells, which are one of the body\u2019s main lines of defense. While the BBB protects the CNS from exposure to toxic or pathogenic substances, it also keeps out the cells that could protect the brain and spinal cord from disease and damage.\u00a0<\/span><\/span>\r\n\r\n<\/section><\/div>\r\nBecause of this privileged blood flow, the CNS needs specialized structures to maintain and regulate it's circulation. This begins with a unique arrangement of blood vessels carrying fresh blood into the CNS. Beyond the supply of blood, the CNS filters that blood into cerebrospinal fluid (CSF), which is then circulated through the cavities of the brain and spinal cord called ventricles. All fluids (venous blood and CSF) return to the general circulation via the great veins of the brain.\r\n\r\n<section id=\"fs-id1050208\" data-depth=\"1\">\r\n<h2>Blood Supply to the Brain<\/h2>\r\n<p id=\"fs-id1497736\">A lack of oxygen to the CNS can be devastating, and the cardiovascular system has specific regulatory reflexes to ensure that the blood supply is not interrupted. There are multiple routes for blood to get into the CNS, with specializations to protect that blood supply and to maximize the ability of the brain to get an uninterrupted perfusion.<\/p>\r\n\r\n<section id=\"fs-id2081500\" data-depth=\"2\">\r\n<h3>Arterial Supply<\/h3>\r\n<p id=\"fs-id1828457\">The major artery carrying recently oxygenated blood away from the heart is the aorta. The very first branches off the aorta supply the heart with nutrients and oxygen. The next branches give rise to the\u00a0<span id=\"term-00001\" data-type=\"term\">common carotid arteries<\/span>, which further branch into the\u00a0<span id=\"term-00002\" data-type=\"term\">internal carotid arteries<\/span>. The external carotid arteries supply blood to the tissues on the surface of the cranium. The bases of the common carotids contain stretch receptors that immediately respond to the drop in blood pressure upon standing. The\u00a0<span id=\"term-00003\" data-type=\"term\">orthostatic reflex<\/span>\u00a0is a reaction to this change in body position, so that blood pressure is maintained against the increasing effect of gravity (orthostatic means \u201cstanding up\u201d). Heart rate increases\u2014a reflex of the sympathetic division of the autonomic nervous system\u2014and this raises blood pressure.<\/p>\r\n\r\n\r\n[caption id=\"attachment_5981\" align=\"aligncenter\" width=\"900\"]<img class=\"wp-image-5981 size-full\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery.png\" alt=\"This figure demonstrates the anatomy of the carotid artery, which delivers oxygen rich blood to the brain.\" width=\"900\" height=\"900\" \/> <strong>The Carotid Artery<\/strong> - The carotid artery carries oxygenated blood to the brain. By BruceBlaus used under Creative Commons license.[\/caption]\r\n<p id=\"fs-id1333836\">The internal carotid artery enters the cranium by passing through a canal in the skull bone. A second set of vessels that supply the CNS are the\u00a0<span id=\"term-00005\" data-type=\"term\">vertebral arteries<\/span>, which merge into the <span id=\"term-00008\" data-type=\"term\">basilar artery<\/span>, the vessel that supplies blood to the brain stem and cerebellum. The left and right internal carotid arteries and branches of the basilar artery all join together in a structure known as the <a href=\"#circleofwillis\"><span id=\"term-00009\" data-type=\"term\">circle of Willis<\/span><\/a>, a confluence of arteries that can maintain perfusion of the brain even if narrowing or a blockage limits flow through one part.<a id=\"circleofwillis\"><\/a><\/p>\r\n\r\n\r\n[caption id=\"attachment_9276\" align=\"aligncenter\" width=\"546\"]<img class=\"size-full wp-image-9276\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN.jpg\" alt=\"This diagram shows a series of interconnected blood vessels and capillaries.\" width=\"546\" height=\"920\" \/> <strong>Circle of Willis<\/strong> - The blood supply to the brain enters through the internal carotid arteries and the vertebral arteries, eventually giving rise to the circle of Willis.[\/caption]\r\n\r\n<div id=\"fs-id1518525\" class=\"anatomy interactive ui-has-child-title\" data-type=\"note\" data-has-label=\"true\" data-label=\"\"><section>\r\n<div class=\"os-note-body\">\r\n<div class=\"textbox shaded\">Watch this\u00a0<a href=\"http:\/\/openstax.org\/l\/bloodflow1\" target=\"_blank\" rel=\"noopener nofollow\">animation<\/a>\u00a0to see how blood flows to the brain and passes through the circle of Willis before being distributed through the cerebrum. The circle of Willis is a specialized arrangement of arteries that ensure constant perfusion of the cerebrum even in the event of a blockage of one of the arteries in the circle. The animation shows the normal direction of flow through the circle of Willis to the middle cerebral artery. Where would the blood come from if there were a blockage just posterior to the middle cerebral artery on the left?<\/div>\r\n<\/div>\r\n<\/section><\/div>\r\n<\/section><section id=\"fs-id1614150\" data-depth=\"2\">\r\n<h2>Venous Return<\/h2>\r\n<p id=\"fs-id1432161\">After passing through the CNS, blood returns to the circulation through a series of\u00a0<span id=\"term-00010\" data-type=\"term\">dural sinuses<\/span> and veins, as shown in<a href=\"#brainsinuses\"> the diagram below<\/a>. The\u00a0<span id=\"term-00011\" data-type=\"term\">superior sagittal sinus<\/span> runs in the groove of the longitudinal fissure, where it absorbs CSF from the meninges (the protective membranes which cover the brain). The superior sagittal sinus drains to the confluence of sinuses, along with the <span id=\"term-00012\" data-type=\"term\">occipital sinuses<\/span>\u00a0and\u00a0<span id=\"term-00013\" data-type=\"term\">straight sinus<\/span>, to then drain into the\u00a0<span id=\"term-00014\" data-type=\"term\">transverse sinuses<\/span>. The transverse sinuses connect to the\u00a0<span id=\"term-00015\" data-type=\"term\">sigmoid sinuses<\/span>, which then connect to the\u00a0<span id=\"term-00016\" data-type=\"term\">jugular veins<\/span>. From there, the blood continues toward the heart to be pumped to the lungs for reoxygenation.<a id=\"brainsinuses\"><\/a><\/p>\r\n\r\n\r\n[caption id=\"attachment_9277\" align=\"aligncenter\" width=\"858\"]<img class=\" wp-image-9277\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-1024x776.jpg\" alt=\"This diagram shows a lateral view of the brain and labels the location of the different sinuses.\" width=\"858\" height=\"650\" \/> <strong>Dural Sinuses and Veins<\/strong> - Blood drains from the brain through a series of sinuses that connect to the jugular veins.[\/caption]\r\n\r\n<\/section><\/section><section id=\"fs-id1212218\" data-depth=\"1\">\r\n<h2 data-type=\"title\">Protective Coverings of the Brain and Spinal Cord<\/h2>\r\n<p id=\"fs-id2026939\">The outer surface of the CNS is covered by a series of membranes composed of connective tissue called the\u00a0<span id=\"term-00017\" data-type=\"term\">meninges<\/span>, which protect the brain. Starting from outside in, the <span id=\"term-00018\" data-type=\"term\">dura mater<\/span> is a thick fibrous layer and a strong protective sheath over the entire brain and spinal cord. It is anchored to the inner surface of the cranium and vertebral cavity. <span style=\"color: #000000\">Next,<\/span> the <span id=\"term-00019\" data-type=\"term\">arachnoid mater<\/span>\u00a0is a membrane of thin fibrous tissue that forms a loose sac around the CNS. Beneath the arachnoid is a thin, filamentous mesh called the\u00a0<span id=\"term-00020\" data-type=\"term\">arachnoid trabeculae<\/span>, which looks like a spider web, giving this layer its name. <span style=\"color: #000000\">Lastly,<\/span> directly adjacent to the surface of the CNS is the <span id=\"term-00021\" data-type=\"term\">pia mater<\/span>, a thin fibrous membrane that follows the convolutions of gyri and sulci in the cerebral cortex and fits into other grooves and indentations.<\/p>\r\n\r\n\r\n[caption id=\"attachment_9278\" align=\"aligncenter\" width=\"949\"]<img class=\"size-full wp-image-9278\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1.jpg\" alt=\"This image shows a cross-section through the brain. The different meningeal layers are labeled.\" width=\"949\" height=\"515\" \/> <strong>Meningeal Layers of Superior Sagittal Sinus<\/strong> - The layers of the meninges in the longitudinal fissure of the superior sagittal sinus are shown, with the dura mater adjacent to the inner surface of the cranium, the pia mater adjacent to the surface of the brain, and the arachnoid and subarachnoid space between them. An arachnoid villus is shown emerging into the dural sinus to allow CSF to filter back into the blood for drainage.[\/caption]\r\n\r\n<section id=\"fs-id921757\" data-depth=\"2\">\r\n<h3 data-type=\"title\">Dura Mater<\/h3>\r\n<p id=\"fs-id1174796\">Like a thick cap covering the brain, the dura mater is a tough outer covering. The name comes from the Latin for \u201ctough mother\u201d to represent its physically protective role. It encloses the entire CNS and the major blood vessels that enter the cranium and vertebral cavity. It is directly attached to the inner surface of the bones of the cranium and to the very end of the vertebral cavity.<\/p>\r\n\r\n<\/section><section id=\"fs-id729752\" data-depth=\"2\">\r\n<h3 data-type=\"title\">Arachnoid Mater<\/h3>\r\n<p id=\"fs-id1614166\">The middle layer of the meninges is the arachnoid, named for the spider-web\u2013like trabeculae between it and the pia mater. The arachnoid defines a sac-like enclosure around the CNS. The trabeculae are found in the\u00a0<span id=\"term-00022\" data-type=\"term\">subarachnoid space<\/span>, which is filled with circulating CSF. The arachnoid emerges into the dural sinuses as the\u00a0<span id=\"term-00023\" data-type=\"term\">arachnoid granulations<\/span>, where the CSF is filtered back into the blood for drainage from the nervous system.<\/p>\r\n<p id=\"fs-id1861831\">The subarachnoid space is filled with circulating CSF, which also provides a liquid cushion to the brain and spinal cord. Similar to clinical blood work, a sample of CSF can be withdrawn to find chemical evidence of neuropathology or metabolic traces of the biochemical functions of nervous tissue.<\/p>\r\n\r\n<\/section><section id=\"fs-id1234000\" data-depth=\"2\">\r\n<h3 data-type=\"title\">Pia Mater<\/h3>\r\n<p id=\"fs-id320754\">The outer surface of the CNS is covered in the thin fibrous membrane of the pia mater. It is thought to have a continuous layer of cells providing a fluid-impermeable membrane. The name pia mater comes from the Latin for \u201ctender mother,\u201d suggesting the thin membrane is a gentle covering for the brain. The pia extends into every convolution of the CNS, lining the inside of the sulci in the cerebral and cerebellar cortices. At the end of the spinal cord, a thin filament extends from the inferior end of CNS at the upper lumbar region of the vertebral column to the sacral end of the vertebral column. Because the spinal cord does not extend through the lower lumbar region of the vertebral column, a needle can be inserted through the dura and arachnoid layers to withdraw CSF. This procedure is called a\u00a0<span id=\"term-00024\" data-type=\"term\">lumbar puncture<\/span>\u00a0and avoids the risk of damaging the central tissue of the spinal cord. Blood vessels that are nourishing the central nervous tissue are between the pia mater and the nervous tissue.<\/p>\r\n\r\n<div id=\"fs-id1074134\" class=\"anatomy disorders ui-has-child-title\" data-type=\"note\"><header><\/header><section>\r\n<div class=\"os-note-body\">\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<p class=\"textbox__title\">DISORDERS OF THE MENINGES<\/p>\r\n\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<p id=\"fs-id1120672\">Meningitis is an inflammation of the meninges, the three layers of fibrous membrane that surround the CNS. Meningitis can be caused by infection by bacteria or viruses. The particular pathogens are not special to meningitis; it is just an inflammation of that specific set of tissues from what might be a broader infection. Bacterial meningitis can be caused by\u00a0<em data-effect=\"italics\">Streptococcus<\/em>,\u00a0<em data-effect=\"italics\">Staphylococcus<\/em>, or the tuberculosis pathogen, among many others. Viral meningitis is usually the result of common enteroviruses (such as those that cause intestinal disorders), but may be the result of the herpes virus or West Nile virus. Bacterial meningitis tends to be more severe.<\/p>\r\n<p id=\"fs-id981313\">The symptoms associated with meningitis can be fever, chills, nausea, vomiting, light sensitivity, soreness of the neck, or severe headache. More important are the neurological symptoms, such as changes in mental state (confusion, memory deficits, and other dementia-type symptoms). A serious risk of meningitis can be damage to peripheral structures because of the nerves that pass through the meninges. Hearing loss is a common result of meningitis.<\/p>\r\n<p id=\"fs-id1233713\">The primary test for meningitis is a lumbar puncture. A needle inserted into the lumbar region of the spinal column through the dura mater and arachnoid membrane into the subarachnoid space can be used to withdraw the fluid for chemical testing. Fatality occurs in 5 to 40 percent of children and 20 to 50 percent of adults with bacterial meningitis. Treatment of bacterial meningitis is through antibiotics, but viral meningitis cannot be treated with antibiotics because viruses do not respond to that type of drug. Fortunately, the viral forms are milder.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n&nbsp;\r\n\r\n<\/div>\r\n<\/section><\/div>\r\n<div id=\"fs-id1037182\" class=\"anatomy interactive ui-has-child-title\" data-type=\"note\" data-has-label=\"true\" data-label=\"\"><section>\r\n<div class=\"os-note-body\">\r\n<div class=\"textbox shaded\">Watch this\u00a0<a href=\"http:\/\/openstax.org\/l\/lumbarpuncture\" target=\"_blank\" rel=\"noopener nofollow\">video<\/a>\u00a0that describes the procedure known as the lumbar puncture, a medical procedure used to sample the CSF. Because of the anatomy of the CNS, it is a relative safe location to insert a needle. Why is the lumbar puncture performed in the lower lumbar area of the vertebral column?<\/div>\r\n<span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1.602em;font-weight: bold\">The Ventricular System<\/span>\r\n\r\n<\/div>\r\n<\/section><\/div>\r\n<\/section><\/section><section id=\"fs-id1319646\" data-depth=\"1\">\r\n<p id=\"fs-id1187632\">Cerebrospinal fluid (CSF) circulates throughout and around the CNS. In other tissues, water and small molecules are filtered through capillaries as the major contributor to the interstitial fluid. In the brain, CSF is produced in special structures to perfuse through the nervous tissue of the CNS and is continuous with the interstitial fluid. Specifically, CSF circulates to remove metabolic wastes from the interstitial fluids of nervous tissues and return them to the blood stream. The\u00a0<span id=\"term-00025\" data-type=\"term\">ventricles<\/span>\u00a0are the open spaces within the brain where CSF circulates. In some of these spaces, CSF is produced by filtering of the blood that is performed by a specialized membrane known as a choroid plexus. The CSF circulates through all of the ventricles to eventually emerge into the subarachnoid space where it will be reabsorbed into the blood.<\/p>\r\n\r\n<section id=\"fs-id1243778\" data-depth=\"2\">\r\n<h3 data-type=\"title\">The Ventricles<\/h3>\r\n<p id=\"fs-id1490421\">There are four ventricles within the brain, all of which developed from the original hollow space within the neural tube, the\u00a0<span id=\"term-00026\" data-type=\"term\">central canal<\/span>. The first two are named the\u00a0<span id=\"term-00027\" data-type=\"term\">lateral ventricles<\/span>\u00a0and are deep within the cerebrum. These ventricles are connected to the\u00a0<span id=\"term-00028\" data-type=\"term\">third ventricle<\/span>\u00a0by two openings called the\u00a0<span id=\"term-00029\" data-type=\"term\">interventricular foramina<\/span>. The third ventricle is the space between the left and right sides of the diencephalon, which opens into the\u00a0<span id=\"term-00030\" data-type=\"term\">cerebral aqueduct<\/span>\u00a0that passes through the midbrain. The aqueduct opens into the\u00a0<span id=\"term-00031\" data-type=\"term\">fourth ventricle<\/span>, which is the space between the cerebellum and the pons and upper medulla, shown below.<\/p>\r\n\r\n\r\n[caption id=\"attachment_9279\" align=\"aligncenter\" width=\"817\"]<img class=\" wp-image-9279\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-1024x666.jpg\" alt=\"This diagram shows the cross section of the brain and the major parts are labeled. Arrows on the figure show the direction of circulation of the cerebro-spinal fluid.\" width=\"817\" height=\"531\" \/> <strong>Cerebrospinal Fluid Circulation<\/strong> - The choroid plexus in the four ventricles produce CSF, which is circulated through the ventricular system and then enters the subarachnoid space through the median and lateral apertures. The CSF is then reabsorbed into the blood at the arachnoid granulations, where the arachnoid membrane emerges into the dural sinuses.[\/caption]\r\n<p id=\"fs-id1335013\"><span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1.42425em;font-style: italic\">Cerebrospinal Fluid Circulation<\/span><\/p>\r\n\r\n<\/section><section id=\"fs-id2925776\" data-depth=\"2\">Cerebrospinal fluid is produced within the ventricles by a type of specialized membrane called a <span id=\"term-00034\" data-type=\"term\">choroid plexus<\/span>. Ependymal cells (one of the types of glial cells described in the introduction to the nervous system) surround blood capillaries and filter the blood to make CSF. The fluid is a clear solution with a limited amount of the constituents of blood. It is essentially water, small molecules, and electrolytes. Oxygen and carbon dioxide are dissolved into the CSF, as they are in blood, and can diffuse between the fluid and the nervous tissue.\r\n<p id=\"fs-id1298119\">The choroid plexuses are found in all four ventricles. Observed in dissection, they appear as soft, fuzzy structures that may still be pink, depending on how well the circulatory system is cleared in preparation of the tissue. The CSF is produced from components extracted from the blood, so its flow out of the ventricles is tied to the pulse of cardiovascular circulation.<\/p>\r\n<p id=\"fs-id1235652\">From the lateral ventricles, the CSF flows into the third ventricle, where more CSF is produced, and then through the cerebral aqueduct into the fourth ventricle where even more CSF is produced. A very small amount of CSF is filtered at any one of the plexuses, for a total of about 500 milliliters daily, but it is continuously made and pulses through the ventricular system, keeping the fluid moving. From the fourth ventricle, CSF can continue down the central canal of the spinal cord, but this is essentially a cul-de-sac, so more of the fluid leaves the ventricular system and moves into the subarachnoid space through the median and lateral apertures.<\/p>\r\n<p id=\"fs-id1493401\">Within the subarachnoid space, the CSF flows around all of the CNS, providing two important functions. As with elsewhere in its circulation, the CSF picks up metabolic wastes from the nervous tissue and moves it out of the CNS. It also acts as a liquid cushion for the brain and spinal cord. By surrounding the entire system in the subarachnoid space, it provides a thin buffer around the organs within the strong, protective dura mater. The arachnoid granulations are outpocketings of the arachnoid membrane into the dural sinuses so that CSF can be reabsorbed into the blood, along with the metabolic wastes. From the dural sinuses, blood drains out of the head and neck through the jugular veins, along with the rest of the circulation for blood, to be reoxygenated by the lungs and wastes to be filtered out by the kidneys.<\/p>\r\n\r\n<div id=\"fs-id1864241\" class=\"anatomy interactive ui-has-child-title\" data-type=\"note\" data-has-label=\"true\" data-label=\"\"><section>\r\n<div class=\"os-note-body\">\r\n<div class=\"textbox shaded\">Watch this\u00a0<a href=\"http:\/\/openstax.org\/l\/CSFflow\" target=\"_blank\" rel=\"noopener nofollow\">animation<\/a> that shows the flow of CSF through the brain and spinal cord, and how it originates from the ventricles and then spreads into the space within the meninges, where the fluids then move into the venous sinuses to return to the cardiovascular circulation. What are the structures that produce CSF and where are they found? How are the structures indicated in this animation?<\/div>\r\n<\/div>\r\n<\/section><\/div>\r\n<div id=\"fs-id2880446\" class=\"anatomy disorders ui-has-child-title\" data-type=\"note\"><header>\r\n<div class=\"textbox textbox--examples\"><header class=\"textbox__header\">\r\n<h3 class=\"os-title\" data-type=\"title\"><span class=\"os-title-label\">DISORDERS OF THE CENTRAL NERVOUS SYSTEM<\/span><\/h3>\r\n<\/header>\r\n<div class=\"textbox__content\">\r\n<p id=\"fs-id1299224\">The supply of blood to the brain is crucial to its ability to perform many functions. Without a steady supply of oxygen, and to a lesser extent glucose, the nervous tissue in the brain cannot keep up its extensive electrical activity. These nutrients get into the brain through the blood, and if blood flow is interrupted, neurological function is compromised.<\/p>\r\n<p id=\"fs-id1488700\">The common name for a disruption of blood supply to the brain is a stroke. It is caused by a blockage to an artery in the brain. The blockage is from some type of embolus: a blood clot, a fat embolus, or an air bubble. When the blood cannot travel through the artery, the surrounding tissue that is deprived starves and dies. Strokes will often result in the loss of very specific functions. A stroke in the lateral medulla, for example, can cause a loss in the ability to swallow. Sometimes, seemingly unrelated functions will be lost because they are dependent on structures in the same region. Along with the swallowing in the previous example, a stroke in that region could affect sensory functions from the face or extremities because important white matter pathways also pass through the lateral medulla. Loss of blood flow to specific regions of the cortex can lead to the loss of specific higher functions, from the ability to recognize faces to the ability to move a particular region of the body. Severe or limited memory loss can be the result of a temporal lobe stroke.<\/p>\r\n<p id=\"fs-id1243214\">Related to strokes are transient ischemic attacks (TIAs), which can also be called \u201cmini-strokes.\u201d These are events in which a physical blockage may be temporary, cutting off the blood supply and oxygen to a region, but not to the extent that it causes cell death in that region. While the neurons in that area are recovering from the event, neurological function may be lost. Function can return if the area is able to recover from the event.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n<\/header><section>\r\n<h1>Adaptation<\/h1>\r\n<p style=\"text-align: start\">This chapter was adapted by Valerie Swanston from the following texts:<\/p>\r\n<p style=\"text-align: start\"><a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\" target=\"_blank\" rel=\"noopener\">Circulation and the Central Nervous System<\/a>\u00a0<strong>in\u00a0<\/strong><a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/\">Anatomy and Physiology<\/a>\u00a0by\u00a0OSCRiceUniversity\u00a0is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">Creative Commons Attribution 4.0 International License<\/a><\/p>\r\n<span style=\"color: #000000\">Chapter 3 - The blood\u2013brain barrier in Handbook of Clinical Neurology by Obermeier B, Verma A, and Ransohoff RM. https:\/\/doi.org\/10.1016\/B978-0-444-63432-0.00003-7<\/span>\r\n\r\n<\/section><\/div>\r\n<\/section><\/section>","rendered":"<div id=\"1\" class=\"ui-has-child-title\" data-type=\"abstract\">\n<section>\n<div class=\"textbox textbox--learning-objectives\">\n<header class=\"textbox__header\">\n<p class=\"textbox__title\">Learning Objectives<\/p>\n<\/header>\n<div class=\"textbox__content\">\n<p id=\"para-00001\">By the end of this section, you will be able to:<\/p>\n<ul id=\"list-00001\">\n<li>Describe the vessels that supply the CNS with blood.<\/li>\n<li>Name the components of the ventricular system and the regions of the brain in which each is located.<\/li>\n<li>Explain the production of cerebrospinal fluid and its flow through the ventricles.<\/li>\n<li>Explain how a disruption in circulation would result in a stroke.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><span style=\"text-align: initial;font-size: 1em\">The CNS is crucial to the operation of the body, and any compromise to the blood flow to the brain and spinal cord can lead to severe difficulties. The CNS has a privileged blood supply, meaning that the entry and exit of substances in the brain is tightly regulated. This is accomplished by a structure known as the blood-brain barrier (BBB). <\/span><span style=\"text-align: initial;font-size: 1em;color: #ff0000\"><span style=\"color: #000000\">Very little can pass through by diffusion. Most substances that cross the wall of a blood vessel into the CNS must do so through an active transport process. Because of this, only specific types of molecules can enter the CNS. Glucose\u2014the primary energy source\u2014is allowed, as are amino acids. Water and some other small particles, like gases and ions, can enter. But most everything else cannot, including white blood cells, which are one of the body\u2019s main lines of defense. While the BBB protects the CNS from exposure to toxic or pathogenic substances, it also keeps out the cells that could protect the brain and spinal cord from disease and damage.\u00a0<\/span><\/span><\/p>\n<\/section>\n<\/div>\n<p>Because of this privileged blood flow, the CNS needs specialized structures to maintain and regulate it&#8217;s circulation. This begins with a unique arrangement of blood vessels carrying fresh blood into the CNS. Beyond the supply of blood, the CNS filters that blood into cerebrospinal fluid (CSF), which is then circulated through the cavities of the brain and spinal cord called ventricles. All fluids (venous blood and CSF) return to the general circulation via the great veins of the brain.<\/p>\n<section id=\"fs-id1050208\" data-depth=\"1\">\n<h2>Blood Supply to the Brain<\/h2>\n<p id=\"fs-id1497736\">A lack of oxygen to the CNS can be devastating, and the cardiovascular system has specific regulatory reflexes to ensure that the blood supply is not interrupted. There are multiple routes for blood to get into the CNS, with specializations to protect that blood supply and to maximize the ability of the brain to get an uninterrupted perfusion.<\/p>\n<section id=\"fs-id2081500\" data-depth=\"2\">\n<h3>Arterial Supply<\/h3>\n<p id=\"fs-id1828457\">The major artery carrying recently oxygenated blood away from the heart is the aorta. The very first branches off the aorta supply the heart with nutrients and oxygen. The next branches give rise to the\u00a0<span id=\"term-00001\" data-type=\"term\">common carotid arteries<\/span>, which further branch into the\u00a0<span id=\"term-00002\" data-type=\"term\">internal carotid arteries<\/span>. The external carotid arteries supply blood to the tissues on the surface of the cranium. The bases of the common carotids contain stretch receptors that immediately respond to the drop in blood pressure upon standing. The\u00a0<span id=\"term-00003\" data-type=\"term\">orthostatic reflex<\/span>\u00a0is a reaction to this change in body position, so that blood pressure is maintained against the increasing effect of gravity (orthostatic means \u201cstanding up\u201d). Heart rate increases\u2014a reflex of the sympathetic division of the autonomic nervous system\u2014and this raises blood pressure.<\/p>\n<figure id=\"attachment_5981\" aria-describedby=\"caption-attachment-5981\" style=\"width: 900px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5981 size-full\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery.png\" alt=\"This figure demonstrates the anatomy of the carotid artery, which delivers oxygen rich blood to the brain.\" width=\"900\" height=\"900\" srcset=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery.png 900w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery-300x300.png 300w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery-150x150.png 150w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery-768x768.png 768w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery-65x65.png 65w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery-225x225.png 225w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2022\/12\/carotid-artery-350x350.png 350w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><figcaption id=\"caption-attachment-5981\" class=\"wp-caption-text\"><strong>The Carotid Artery<\/strong> &#8211; The carotid artery carries oxygenated blood to the brain. By BruceBlaus used under Creative Commons license.<\/figcaption><\/figure>\n<p id=\"fs-id1333836\">The internal carotid artery enters the cranium by passing through a canal in the skull bone. A second set of vessels that supply the CNS are the\u00a0<span id=\"term-00005\" data-type=\"term\">vertebral arteries<\/span>, which merge into the <span id=\"term-00008\" data-type=\"term\">basilar artery<\/span>, the vessel that supplies blood to the brain stem and cerebellum. The left and right internal carotid arteries and branches of the basilar artery all join together in a structure known as the <a href=\"#circleofwillis\"><span id=\"term-00009\" data-type=\"term\">circle of Willis<\/span><\/a>, a confluence of arteries that can maintain perfusion of the brain even if narrowing or a blockage limits flow through one part.<a id=\"circleofwillis\"><\/a><\/p>\n<figure id=\"attachment_9276\" aria-describedby=\"caption-attachment-9276\" style=\"width: 546px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9276\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN.jpg\" alt=\"This diagram shows a series of interconnected blood vessels and capillaries.\" width=\"546\" height=\"920\" srcset=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN.jpg 546w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN-178x300.jpg 178w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN-65x110.jpg 65w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN-225x379.jpg 225w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1314_Circle_of_WillisN-350x590.jpg 350w\" sizes=\"auto, (max-width: 546px) 100vw, 546px\" \/><figcaption id=\"caption-attachment-9276\" class=\"wp-caption-text\"><strong>Circle of Willis<\/strong> &#8211; The blood supply to the brain enters through the internal carotid arteries and the vertebral arteries, eventually giving rise to the circle of Willis.<\/figcaption><\/figure>\n<div id=\"fs-id1518525\" class=\"anatomy interactive ui-has-child-title\" data-type=\"note\" data-has-label=\"true\" data-label=\"\">\n<section>\n<div class=\"os-note-body\">\n<div class=\"textbox shaded\">Watch this\u00a0<a href=\"http:\/\/openstax.org\/l\/bloodflow1\" target=\"_blank\" rel=\"noopener nofollow\">animation<\/a>\u00a0to see how blood flows to the brain and passes through the circle of Willis before being distributed through the cerebrum. The circle of Willis is a specialized arrangement of arteries that ensure constant perfusion of the cerebrum even in the event of a blockage of one of the arteries in the circle. The animation shows the normal direction of flow through the circle of Willis to the middle cerebral artery. Where would the blood come from if there were a blockage just posterior to the middle cerebral artery on the left?<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/section>\n<section id=\"fs-id1614150\" data-depth=\"2\">\n<h2>Venous Return<\/h2>\n<p id=\"fs-id1432161\">After passing through the CNS, blood returns to the circulation through a series of\u00a0<span id=\"term-00010\" data-type=\"term\">dural sinuses<\/span> and veins, as shown in<a href=\"#brainsinuses\"> the diagram below<\/a>. The\u00a0<span id=\"term-00011\" data-type=\"term\">superior sagittal sinus<\/span> runs in the groove of the longitudinal fissure, where it absorbs CSF from the meninges (the protective membranes which cover the brain). The superior sagittal sinus drains to the confluence of sinuses, along with the <span id=\"term-00012\" data-type=\"term\">occipital sinuses<\/span>\u00a0and\u00a0<span id=\"term-00013\" data-type=\"term\">straight sinus<\/span>, to then drain into the\u00a0<span id=\"term-00014\" data-type=\"term\">transverse sinuses<\/span>. The transverse sinuses connect to the\u00a0<span id=\"term-00015\" data-type=\"term\">sigmoid sinuses<\/span>, which then connect to the\u00a0<span id=\"term-00016\" data-type=\"term\">jugular veins<\/span>. From there, the blood continues toward the heart to be pumped to the lungs for reoxygenation.<a id=\"brainsinuses\"><\/a><\/p>\n<figure id=\"attachment_9277\" aria-describedby=\"caption-attachment-9277\" style=\"width: 858px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9277\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-1024x776.jpg\" alt=\"This diagram shows a lateral view of the brain and labels the location of the different sinuses.\" width=\"858\" height=\"650\" srcset=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-1024x776.jpg 1024w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-300x227.jpg 300w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-768x582.jpg 768w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-65x49.jpg 65w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-225x171.jpg 225w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses-350x265.jpg 350w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1315_Brain_Sinuses.jpg 1090w\" sizes=\"auto, (max-width: 858px) 100vw, 858px\" \/><figcaption id=\"caption-attachment-9277\" class=\"wp-caption-text\"><strong>Dural Sinuses and Veins<\/strong> &#8211; Blood drains from the brain through a series of sinuses that connect to the jugular veins.<\/figcaption><\/figure>\n<\/section>\n<\/section>\n<section id=\"fs-id1212218\" data-depth=\"1\">\n<h2 data-type=\"title\">Protective Coverings of the Brain and Spinal Cord<\/h2>\n<p id=\"fs-id2026939\">The outer surface of the CNS is covered by a series of membranes composed of connective tissue called the\u00a0<span id=\"term-00017\" data-type=\"term\">meninges<\/span>, which protect the brain. Starting from outside in, the <span id=\"term-00018\" data-type=\"term\">dura mater<\/span> is a thick fibrous layer and a strong protective sheath over the entire brain and spinal cord. It is anchored to the inner surface of the cranium and vertebral cavity. <span style=\"color: #000000\">Next,<\/span> the <span id=\"term-00019\" data-type=\"term\">arachnoid mater<\/span>\u00a0is a membrane of thin fibrous tissue that forms a loose sac around the CNS. Beneath the arachnoid is a thin, filamentous mesh called the\u00a0<span id=\"term-00020\" data-type=\"term\">arachnoid trabeculae<\/span>, which looks like a spider web, giving this layer its name. <span style=\"color: #000000\">Lastly,<\/span> directly adjacent to the surface of the CNS is the <span id=\"term-00021\" data-type=\"term\">pia mater<\/span>, a thin fibrous membrane that follows the convolutions of gyri and sulci in the cerebral cortex and fits into other grooves and indentations.<\/p>\n<figure id=\"attachment_9278\" aria-describedby=\"caption-attachment-9278\" style=\"width: 949px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9278\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1.jpg\" alt=\"This image shows a cross-section through the brain. The different meningeal layers are labeled.\" width=\"949\" height=\"515\" srcset=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1.jpg 949w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1-300x163.jpg 300w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1-768x417.jpg 768w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1-65x35.jpg 65w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1-225x122.jpg 225w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1316_Meningeal_LayersN1-350x190.jpg 350w\" sizes=\"auto, (max-width: 949px) 100vw, 949px\" \/><figcaption id=\"caption-attachment-9278\" class=\"wp-caption-text\"><strong>Meningeal Layers of Superior Sagittal Sinus<\/strong> &#8211; The layers of the meninges in the longitudinal fissure of the superior sagittal sinus are shown, with the dura mater adjacent to the inner surface of the cranium, the pia mater adjacent to the surface of the brain, and the arachnoid and subarachnoid space between them. An arachnoid villus is shown emerging into the dural sinus to allow CSF to filter back into the blood for drainage.<\/figcaption><\/figure>\n<section id=\"fs-id921757\" data-depth=\"2\">\n<h3 data-type=\"title\">Dura Mater<\/h3>\n<p id=\"fs-id1174796\">Like a thick cap covering the brain, the dura mater is a tough outer covering. The name comes from the Latin for \u201ctough mother\u201d to represent its physically protective role. It encloses the entire CNS and the major blood vessels that enter the cranium and vertebral cavity. It is directly attached to the inner surface of the bones of the cranium and to the very end of the vertebral cavity.<\/p>\n<\/section>\n<section id=\"fs-id729752\" data-depth=\"2\">\n<h3 data-type=\"title\">Arachnoid Mater<\/h3>\n<p id=\"fs-id1614166\">The middle layer of the meninges is the arachnoid, named for the spider-web\u2013like trabeculae between it and the pia mater. The arachnoid defines a sac-like enclosure around the CNS. The trabeculae are found in the\u00a0<span id=\"term-00022\" data-type=\"term\">subarachnoid space<\/span>, which is filled with circulating CSF. The arachnoid emerges into the dural sinuses as the\u00a0<span id=\"term-00023\" data-type=\"term\">arachnoid granulations<\/span>, where the CSF is filtered back into the blood for drainage from the nervous system.<\/p>\n<p id=\"fs-id1861831\">The subarachnoid space is filled with circulating CSF, which also provides a liquid cushion to the brain and spinal cord. Similar to clinical blood work, a sample of CSF can be withdrawn to find chemical evidence of neuropathology or metabolic traces of the biochemical functions of nervous tissue.<\/p>\n<\/section>\n<section id=\"fs-id1234000\" data-depth=\"2\">\n<h3 data-type=\"title\">Pia Mater<\/h3>\n<p id=\"fs-id320754\">The outer surface of the CNS is covered in the thin fibrous membrane of the pia mater. It is thought to have a continuous layer of cells providing a fluid-impermeable membrane. The name pia mater comes from the Latin for \u201ctender mother,\u201d suggesting the thin membrane is a gentle covering for the brain. The pia extends into every convolution of the CNS, lining the inside of the sulci in the cerebral and cerebellar cortices. At the end of the spinal cord, a thin filament extends from the inferior end of CNS at the upper lumbar region of the vertebral column to the sacral end of the vertebral column. Because the spinal cord does not extend through the lower lumbar region of the vertebral column, a needle can be inserted through the dura and arachnoid layers to withdraw CSF. This procedure is called a\u00a0<span id=\"term-00024\" data-type=\"term\">lumbar puncture<\/span>\u00a0and avoids the risk of damaging the central tissue of the spinal cord. Blood vessels that are nourishing the central nervous tissue are between the pia mater and the nervous tissue.<\/p>\n<div id=\"fs-id1074134\" class=\"anatomy disorders ui-has-child-title\" data-type=\"note\">\n<header><\/header>\n<section>\n<div class=\"os-note-body\">\n<div class=\"textbox textbox--examples\">\n<header class=\"textbox__header\">\n<p class=\"textbox__title\">DISORDERS OF THE MENINGES<\/p>\n<\/header>\n<div class=\"textbox__content\">\n<p id=\"fs-id1120672\">Meningitis is an inflammation of the meninges, the three layers of fibrous membrane that surround the CNS. Meningitis can be caused by infection by bacteria or viruses. The particular pathogens are not special to meningitis; it is just an inflammation of that specific set of tissues from what might be a broader infection. Bacterial meningitis can be caused by\u00a0<em data-effect=\"italics\">Streptococcus<\/em>,\u00a0<em data-effect=\"italics\">Staphylococcus<\/em>, or the tuberculosis pathogen, among many others. Viral meningitis is usually the result of common enteroviruses (such as those that cause intestinal disorders), but may be the result of the herpes virus or West Nile virus. Bacterial meningitis tends to be more severe.<\/p>\n<p id=\"fs-id981313\">The symptoms associated with meningitis can be fever, chills, nausea, vomiting, light sensitivity, soreness of the neck, or severe headache. More important are the neurological symptoms, such as changes in mental state (confusion, memory deficits, and other dementia-type symptoms). A serious risk of meningitis can be damage to peripheral structures because of the nerves that pass through the meninges. Hearing loss is a common result of meningitis.<\/p>\n<p id=\"fs-id1233713\">The primary test for meningitis is a lumbar puncture. A needle inserted into the lumbar region of the spinal column through the dura mater and arachnoid membrane into the subarachnoid space can be used to withdraw the fluid for chemical testing. Fatality occurs in 5 to 40 percent of children and 20 to 50 percent of adults with bacterial meningitis. Treatment of bacterial meningitis is through antibiotics, but viral meningitis cannot be treated with antibiotics because viruses do not respond to that type of drug. Fortunately, the viral forms are milder.<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<\/section>\n<\/div>\n<div id=\"fs-id1037182\" class=\"anatomy interactive ui-has-child-title\" data-type=\"note\" data-has-label=\"true\" data-label=\"\">\n<section>\n<div class=\"os-note-body\">\n<div class=\"textbox shaded\">Watch this\u00a0<a href=\"http:\/\/openstax.org\/l\/lumbarpuncture\" target=\"_blank\" rel=\"noopener nofollow\">video<\/a>\u00a0that describes the procedure known as the lumbar puncture, a medical procedure used to sample the CSF. Because of the anatomy of the CNS, it is a relative safe location to insert a needle. Why is the lumbar puncture performed in the lower lumbar area of the vertebral column?<\/div>\n<p><span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1.602em;font-weight: bold\">The Ventricular System<\/span><\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/section>\n<\/section>\n<section id=\"fs-id1319646\" data-depth=\"1\">\n<p id=\"fs-id1187632\">Cerebrospinal fluid (CSF) circulates throughout and around the CNS. In other tissues, water and small molecules are filtered through capillaries as the major contributor to the interstitial fluid. In the brain, CSF is produced in special structures to perfuse through the nervous tissue of the CNS and is continuous with the interstitial fluid. Specifically, CSF circulates to remove metabolic wastes from the interstitial fluids of nervous tissues and return them to the blood stream. The\u00a0<span id=\"term-00025\" data-type=\"term\">ventricles<\/span>\u00a0are the open spaces within the brain where CSF circulates. In some of these spaces, CSF is produced by filtering of the blood that is performed by a specialized membrane known as a choroid plexus. The CSF circulates through all of the ventricles to eventually emerge into the subarachnoid space where it will be reabsorbed into the blood.<\/p>\n<section id=\"fs-id1243778\" data-depth=\"2\">\n<h3 data-type=\"title\">The Ventricles<\/h3>\n<p id=\"fs-id1490421\">There are four ventricles within the brain, all of which developed from the original hollow space within the neural tube, the\u00a0<span id=\"term-00026\" data-type=\"term\">central canal<\/span>. The first two are named the\u00a0<span id=\"term-00027\" data-type=\"term\">lateral ventricles<\/span>\u00a0and are deep within the cerebrum. These ventricles are connected to the\u00a0<span id=\"term-00028\" data-type=\"term\">third ventricle<\/span>\u00a0by two openings called the\u00a0<span id=\"term-00029\" data-type=\"term\">interventricular foramina<\/span>. The third ventricle is the space between the left and right sides of the diencephalon, which opens into the\u00a0<span id=\"term-00030\" data-type=\"term\">cerebral aqueduct<\/span>\u00a0that passes through the midbrain. The aqueduct opens into the\u00a0<span id=\"term-00031\" data-type=\"term\">fourth ventricle<\/span>, which is the space between the cerebellum and the pons and upper medulla, shown below.<\/p>\n<figure id=\"attachment_9279\" aria-describedby=\"caption-attachment-9279\" style=\"width: 817px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9279\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-1024x666.jpg\" alt=\"This diagram shows the cross section of the brain and the major parts are labeled. Arrows on the figure show the direction of circulation of the cerebro-spinal fluid.\" width=\"817\" height=\"531\" srcset=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-1024x666.jpg 1024w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-300x195.jpg 300w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-768x500.jpg 768w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-65x42.jpg 65w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-225x146.jpg 225w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2-350x228.jpg 350w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/08\/1317_CFS_Circulation2.jpg 1065w\" sizes=\"auto, (max-width: 817px) 100vw, 817px\" \/><figcaption id=\"caption-attachment-9279\" class=\"wp-caption-text\"><strong>Cerebrospinal Fluid Circulation<\/strong> &#8211; The choroid plexus in the four ventricles produce CSF, which is circulated through the ventricular system and then enters the subarachnoid space through the median and lateral apertures. The CSF is then reabsorbed into the blood at the arachnoid granulations, where the arachnoid membrane emerges into the dural sinuses.<\/figcaption><\/figure>\n<p id=\"fs-id1335013\"><span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1.42425em;font-style: italic\">Cerebrospinal Fluid Circulation<\/span><\/p>\n<\/section>\n<section id=\"fs-id2925776\" data-depth=\"2\">Cerebrospinal fluid is produced within the ventricles by a type of specialized membrane called a <span id=\"term-00034\" data-type=\"term\">choroid plexus<\/span>. Ependymal cells (one of the types of glial cells described in the introduction to the nervous system) surround blood capillaries and filter the blood to make CSF. The fluid is a clear solution with a limited amount of the constituents of blood. It is essentially water, small molecules, and electrolytes. Oxygen and carbon dioxide are dissolved into the CSF, as they are in blood, and can diffuse between the fluid and the nervous tissue.<\/p>\n<p id=\"fs-id1298119\">The choroid plexuses are found in all four ventricles. Observed in dissection, they appear as soft, fuzzy structures that may still be pink, depending on how well the circulatory system is cleared in preparation of the tissue. The CSF is produced from components extracted from the blood, so its flow out of the ventricles is tied to the pulse of cardiovascular circulation.<\/p>\n<p id=\"fs-id1235652\">From the lateral ventricles, the CSF flows into the third ventricle, where more CSF is produced, and then through the cerebral aqueduct into the fourth ventricle where even more CSF is produced. A very small amount of CSF is filtered at any one of the plexuses, for a total of about 500 milliliters daily, but it is continuously made and pulses through the ventricular system, keeping the fluid moving. From the fourth ventricle, CSF can continue down the central canal of the spinal cord, but this is essentially a cul-de-sac, so more of the fluid leaves the ventricular system and moves into the subarachnoid space through the median and lateral apertures.<\/p>\n<p id=\"fs-id1493401\">Within the subarachnoid space, the CSF flows around all of the CNS, providing two important functions. As with elsewhere in its circulation, the CSF picks up metabolic wastes from the nervous tissue and moves it out of the CNS. It also acts as a liquid cushion for the brain and spinal cord. By surrounding the entire system in the subarachnoid space, it provides a thin buffer around the organs within the strong, protective dura mater. The arachnoid granulations are outpocketings of the arachnoid membrane into the dural sinuses so that CSF can be reabsorbed into the blood, along with the metabolic wastes. From the dural sinuses, blood drains out of the head and neck through the jugular veins, along with the rest of the circulation for blood, to be reoxygenated by the lungs and wastes to be filtered out by the kidneys.<\/p>\n<div id=\"fs-id1864241\" class=\"anatomy interactive ui-has-child-title\" data-type=\"note\" data-has-label=\"true\" data-label=\"\">\n<section>\n<div class=\"os-note-body\">\n<div class=\"textbox shaded\">Watch this\u00a0<a href=\"http:\/\/openstax.org\/l\/CSFflow\" target=\"_blank\" rel=\"noopener nofollow\">animation<\/a> that shows the flow of CSF through the brain and spinal cord, and how it originates from the ventricles and then spreads into the space within the meninges, where the fluids then move into the venous sinuses to return to the cardiovascular circulation. What are the structures that produce CSF and where are they found? How are the structures indicated in this animation?<\/div>\n<\/div>\n<\/section>\n<\/div>\n<div id=\"fs-id2880446\" class=\"anatomy disorders ui-has-child-title\" data-type=\"note\">\n<header>\n<div class=\"textbox textbox--examples\"><\/div>\n<\/header>\n<header class=\"textbox__header\">\n<h3 class=\"os-title\" data-type=\"title\"><span class=\"os-title-label\">DISORDERS OF THE CENTRAL NERVOUS SYSTEM<\/span><\/h3>\n<\/header>\n<div class=\"textbox__content\">\n<p id=\"fs-id1299224\">The supply of blood to the brain is crucial to its ability to perform many functions. Without a steady supply of oxygen, and to a lesser extent glucose, the nervous tissue in the brain cannot keep up its extensive electrical activity. These nutrients get into the brain through the blood, and if blood flow is interrupted, neurological function is compromised.<\/p>\n<p id=\"fs-id1488700\">The common name for a disruption of blood supply to the brain is a stroke. It is caused by a blockage to an artery in the brain. The blockage is from some type of embolus: a blood clot, a fat embolus, or an air bubble. When the blood cannot travel through the artery, the surrounding tissue that is deprived starves and dies. Strokes will often result in the loss of very specific functions. A stroke in the lateral medulla, for example, can cause a loss in the ability to swallow. Sometimes, seemingly unrelated functions will be lost because they are dependent on structures in the same region. Along with the swallowing in the previous example, a stroke in that region could affect sensory functions from the face or extremities because important white matter pathways also pass through the lateral medulla. Loss of blood flow to specific regions of the cortex can lead to the loss of specific higher functions, from the ability to recognize faces to the ability to move a particular region of the body. Severe or limited memory loss can be the result of a temporal lobe stroke.<\/p>\n<p id=\"fs-id1243214\">Related to strokes are transient ischemic attacks (TIAs), which can also be called \u201cmini-strokes.\u201d These are events in which a physical blockage may be temporary, cutting off the blood supply and oxygen to a region, but not to the extent that it causes cell death in that region. While the neurons in that area are recovering from the event, neurological function may be lost. Function can return if the area is able to recover from the event.<\/p>\n<\/div>\n<\/div>\n<section>\n<h1>Adaptation<\/h1>\n<p style=\"text-align: start\">This chapter was adapted by Valerie Swanston from the following texts:<\/p>\n<p style=\"text-align: start\"><a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\" target=\"_blank\" rel=\"noopener\">Circulation and the Central Nervous System<\/a>\u00a0<strong>in\u00a0<\/strong><a href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/\">Anatomy and Physiology<\/a>\u00a0by\u00a0OSCRiceUniversity\u00a0is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">Creative Commons Attribution 4.0 International License<\/a><\/p>\n<p><span style=\"color: #000000\">Chapter 3 &#8211; The blood\u2013brain barrier in Handbook of Clinical Neurology by Obermeier B, Verma A, and Ransohoff RM. https:\/\/doi.org\/10.1016\/B978-0-444-63432-0.00003-7<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<div class=\"media-attributions clear\" prefix:cc=\"http:\/\/creativecommons.org\/ns#\" prefix:dc=\"http:\/\/purl.org\/dc\/terms\/\"><h2>Media Attributions<\/h2><ul><li about=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/a\/a4\/Blausen_0170_CarotidArteries.png\"><a rel=\"cc:attributionURL\" href=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/a\/a4\/Blausen_0170_CarotidArteries.png\" property=\"dc:title\">carotid artery<\/a>  &copy;  BruceBlaus    is licensed under a  <a rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY (Attribution)<\/a> license<\/li><li about=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\"><a rel=\"cc:attributionURL\" href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\" property=\"dc:title\">1314_Circle_of_WillisN<\/a>  &copy;  OSCRiceUniversity    is licensed under a  <a rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY (Attribution)<\/a> license<\/li><li about=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\"><a rel=\"cc:attributionURL\" href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\" property=\"dc:title\">1315_Brain_Sinuses<\/a>  &copy;  OSCRiceUniversity    is licensed under a  <a rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY (Attribution)<\/a> license<\/li><li about=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\"><a rel=\"cc:attributionURL\" href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\" property=\"dc:title\">1316_Meningeal_LayersN1<\/a>  &copy;  OSCRiceUniversity    is licensed under a  <a rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY (Attribution)<\/a> license<\/li><li about=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\"><a rel=\"cc:attributionURL\" href=\"https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/13-3-circulation-and-the-central-nervous-system\" property=\"dc:title\">1317_CFS_Circulation2<\/a>  &copy;  OSCRiceUniversity    is licensed under a  <a rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY (Attribution)<\/a> license<\/li><\/ul><\/div>","protected":false},"author":1076,"menu_order":6,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":["j-gordon-betts-wmw0km2yc4-zwjtwys5dl","james-a-wise-oouiyvzss6-eyteble7py","kelly-a-young-kvrvdtgd7l-hnhru8nhag","eddie-johnson-sztuysjpin-8bz8zd3gz0","brandon-poe-fjzinvjayf-j8fjw2ni6s","dean-h-kruse-fjrrkqc7wi-qwjdqlbqf5","oksana-korol-wz71t6zrpc-kgysk8vqqd","jody-e-johnson-gmyqec8nhu-y4rakvwrep","mark-womble-4haloxvxcz-ngcftjhvxv","peter-desaix-nez4h62x7j-xmejobczo0"],"pb_section_license":""},"chapter-type":[],"contributor":[260,273,290,322,339,355,381,402,453,466],"license":[],"class_list":["post-7643","chapter","type-chapter","status-publish","hentry","contributor-brandon-poe-fjzinvjayf-j8fjw2ni6s","contributor-dean-h-kruse-fjrrkqc7wi-qwjdqlbqf5","contributor-eddie-johnson-sztuysjpin-8bz8zd3gz0","contributor-j-gordon-betts-wmw0km2yc4-zwjtwys5dl","contributor-james-a-wise-oouiyvzss6-eyteble7py","contributor-jody-e-johnson-gmyqec8nhu-y4rakvwrep","contributor-kelly-a-young-kvrvdtgd7l-hnhru8nhag","contributor-mark-womble-4haloxvxcz-ngcftjhvxv","contributor-oksana-korol-wz71t6zrpc-kgysk8vqqd","contributor-peter-desaix-nez4h62x7j-xmejobczo0"],"part":7631,"_links":{"self":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/7643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/users\/1076"}],"version-history":[{"count":8,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/7643\/revisions"}],"predecessor-version":[{"id":9281,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/7643\/revisions\/9281"}],"part":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/parts\/7631"}],"metadata":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/7643\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/media?parent=7643"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapter-type?post=7643"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/contributor?post=7643"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/license?post=7643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}