{"id":8357,"date":"2025-08-23T23:53:05","date_gmt":"2025-08-24T03:53:05","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/pathology\/?post_type=chapter&#038;p=8357"},"modified":"2025-08-23T23:53:35","modified_gmt":"2025-08-24T03:53:35","slug":"immunity-overview","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/pathology\/chapter\/immunity-overview\/","title":{"raw":"Immunity Overview","rendered":"Immunity Overview"},"content":{"raw":"<div class=\"titlepage\">\r\n\r\n[caption id=\"attachment_8315\" align=\"aligncenter\" width=\"1024\"]<img class=\"wp-image-8315 size-full\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1.jpg\" alt=\"The image shows a blood smear with the presence of purple-stained neutrophil and eosinophil floating among red blood cells in this blood smear.\" width=\"1024\" height=\"511\" \/> In this compound light micrograph purple-stained neutrophil (upper left) and eosinophil (lower right) are white blood cells that float among red blood cells in this blood smear. Neutrophils provide an early, rapid, and nonspecific defense against invading pathogens. Eosinophils play a variety of roles in the immune response. Red blood cells are about 7\u20138 \u00b5m in diameter, and a neutrophil is about 10\u201312\u00b5m. (Credit: modification of work by Dr. David Csaba)[\/caption]\r\n\r\n<\/div>\r\n<div id=\"m44817\" class=\"introduction\">\r\n\r\n<span id=\"m44817-fs-idp151645776\"> <\/span>The environment consists of numerous [pb_glossary id=\"8512\"]pathogens[\/pb_glossary], which are agents, usually microorganisms, that cause diseases in their hosts. A <span id=\"m44817-autoid-cnx2dbk-id1470649\"><\/span>[pb_glossary id=\"8513\"]<span id=\"m44817-autoid-cnx2dbk-id1470649\"> <\/span>host[\/pb_glossary]\u00a0is the organism that is invaded and often harmed by a pathogen. Pathogens include bacteria, protists, fungi and other infectious organisms. We are constantly exposed to pathogens in food and water, on surfaces, and in the air. Mammalian immune systems evolved for protection from such pathogens; they are composed of an extremely diverse array of specialized cells and soluble molecules that coordinate a rapid and flexible defense system capable of providing protection from a majority of these disease agents.\r\n\r\n<span id=\"m44817-fs-idm59674416\"> <\/span>Components of the immune system constantly search the body for signs of pathogens. When pathogens are found, immune factors are mobilized to the site of an infection. The immune factors identify the nature of the pathogen, strengthen the corresponding cells and molecules to combat it efficiently, and then halt the immune response after the infection is cleared to avoid unnecessary host cell damage. The immune system can remember pathogens to which it has been exposed to create a more efficient response upon re-exposure. This memory can last several decades. Features of the immune system, such as pathogen identification, specific response, amplification, retreat, and remembrance are essential for survival against pathogens. The immune response can be classified as either innate or active. The innate immune response is always present and attempts to defend against all pathogens rather than focusing on specific ones. Conversely, the adaptive immune response stores information about past infections and mounts pathogen-specific defenses.\r\n<h1>Adaption<\/h1>\r\n<p style=\"text-align: start\">This chapter is adapted <span style=\"text-align: initial;font-size: 1em\">by Morgan Alford <\/span>from the following text:<\/p>\r\n<a href=\"https:\/\/opentextbc.ca\/biology\/part\/chapter-23-the-immune-system\/\">The Immune System<\/a> in <a href=\"https:\/\/opentextbc.ca\/biology\/\">Concepts of Biology, First Canadian Edition<\/a> by Drs. Jane Gair and Charles Molnar is licensed under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">Creative Commons Attribution 4.0 International License<\/a>.\r\n\r\n<\/div>","rendered":"<div class=\"titlepage\">\n<figure id=\"attachment_8315\" aria-describedby=\"caption-attachment-8315\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8315 size-full\" src=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1.jpg\" alt=\"The image shows a blood smear with the presence of purple-stained neutrophil and eosinophil floating among red blood cells in this blood smear.\" width=\"1024\" height=\"511\" srcset=\"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1.jpg 1024w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1-300x150.jpg 300w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1-768x383.jpg 768w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1-65x32.jpg 65w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1-225x112.jpg 225w, https:\/\/pressbooks.bccampus.ca\/pathology\/wp-content\/uploads\/sites\/1260\/2025\/02\/Figure_42_00_01-1024x511-1-350x175.jpg 350w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-8315\" class=\"wp-caption-text\">In this compound light micrograph purple-stained neutrophil (upper left) and eosinophil (lower right) are white blood cells that float among red blood cells in this blood smear. Neutrophils provide an early, rapid, and nonspecific defense against invading pathogens. Eosinophils play a variety of roles in the immune response. Red blood cells are about 7\u20138 \u00b5m in diameter, and a neutrophil is about 10\u201312\u00b5m. (Credit: modification of work by Dr. David Csaba)<\/figcaption><\/figure>\n<\/div>\n<div id=\"m44817\" class=\"introduction\">\n<p><span id=\"m44817-fs-idp151645776\"> <\/span>The environment consists of numerous <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_8357_8512\">pathogens<\/a>, which are agents, usually microorganisms, that cause diseases in their hosts. A <span id=\"m44817-autoid-cnx2dbk-id1470649\"><\/span><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_8357_8513\"><span id=\"m44817-autoid-cnx2dbk-id1470649\"> <\/span>host<\/a>\u00a0is the organism that is invaded and often harmed by a pathogen. Pathogens include bacteria, protists, fungi and other infectious organisms. We are constantly exposed to pathogens in food and water, on surfaces, and in the air. Mammalian immune systems evolved for protection from such pathogens; they are composed of an extremely diverse array of specialized cells and soluble molecules that coordinate a rapid and flexible defense system capable of providing protection from a majority of these disease agents.<\/p>\n<p><span id=\"m44817-fs-idm59674416\"> <\/span>Components of the immune system constantly search the body for signs of pathogens. When pathogens are found, immune factors are mobilized to the site of an infection. The immune factors identify the nature of the pathogen, strengthen the corresponding cells and molecules to combat it efficiently, and then halt the immune response after the infection is cleared to avoid unnecessary host cell damage. The immune system can remember pathogens to which it has been exposed to create a more efficient response upon re-exposure. This memory can last several decades. Features of the immune system, such as pathogen identification, specific response, amplification, retreat, and remembrance are essential for survival against pathogens. The immune response can be classified as either innate or active. The innate immune response is always present and attempts to defend against all pathogens rather than focusing on specific ones. Conversely, the adaptive immune response stores information about past infections and mounts pathogen-specific defenses.<\/p>\n<h1>Adaption<\/h1>\n<p style=\"text-align: start\">This chapter is adapted <span style=\"text-align: initial;font-size: 1em\">by Morgan Alford <\/span>from the following text:<\/p>\n<p><a href=\"https:\/\/opentextbc.ca\/biology\/part\/chapter-23-the-immune-system\/\">The Immune System<\/a> in <a href=\"https:\/\/opentextbc.ca\/biology\/\">Concepts of Biology, First Canadian Edition<\/a> by Drs. Jane Gair and Charles Molnar is licensed under a <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<div class=\"media-attributions clear\" prefix:cc=\"http:\/\/creativecommons.org\/ns#\" prefix:dc=\"http:\/\/purl.org\/dc\/terms\/\"><h2>Media Attributions<\/h2><ul><li about=\"https:\/\/opentextbc.ca\/biology\/part\/chapter-23-the-immune-system\/\"><a rel=\"cc:attributionURL\" href=\"https:\/\/opentextbc.ca\/biology\/part\/chapter-23-the-immune-system\/\" property=\"dc:title\">Figure_42_00_01-1024&#215;511-1<\/a>  &copy;  Charles Molnar and Jane Gair    is licensed under a  <a rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY (Attribution)<\/a> license<\/li><\/ul><\/div><div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_8357_8512\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_8357_8512\"><div tabindex=\"-1\"><p>an agent, usually a microbe, that causes disease in the organisms they invade<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_8357_8513\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_8357_8513\"><div tabindex=\"-1\"><p>an organism that is invaded by a pathogen or parasite<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"author":1232,"menu_order":3,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":["morganalford","c-molnar","j-gair"],"pb_section_license":"cc-by"},"chapter-type":[],"contributor":[536,537,535],"license":[52],"class_list":["post-8357","chapter","type-chapter","status-publish","hentry","contributor-c-molnar","contributor-j-gair","contributor-morganalford","license-cc-by"],"part":8316,"_links":{"self":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/8357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/users\/1232"}],"version-history":[{"count":6,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/8357\/revisions"}],"predecessor-version":[{"id":9499,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/8357\/revisions\/9499"}],"part":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/parts\/8316"}],"metadata":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapters\/8357\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/media?parent=8357"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/pressbooks\/v2\/chapter-type?post=8357"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/contributor?post=8357"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pathology\/wp-json\/wp\/v2\/license?post=8357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}