{"id":1238,"date":"2023-01-08T02:57:37","date_gmt":"2023-01-08T07:57:37","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/?post_type=chapter&#038;p=1238"},"modified":"2023-01-17T18:37:26","modified_gmt":"2023-01-17T23:37:26","slug":"antimicrobials-antibiotics","status":"publish","type":"chapter","link":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/chapter\/antimicrobials-antibiotics\/","title":{"raw":"Antimicrobials: Antibiotics","rendered":"Antimicrobials: Antibiotics"},"content":{"raw":"<div>\r\n<h1>OTC Topical Antibiotics<\/h1>\r\n<\/div>\r\n<div>\r\n\r\nBacitracin: Bactericidal against Gm+. Can develop allergic contact dermatitis with prolonged use.\r\n\r\nPolymyxin B: Bactericidal against Gm-. Often combined with bacitracin.\r\n\r\nNeomycin: Bactericidal against Gm+ and Gm-, good S. Aureus coverage. Can develop allergic contact dermatitis with prolonged use.\u00a0 Often combined with bacitracin and polymyxin B.\r\n\r\n<\/div>\r\n<div>\r\n<h1>Prescription Topical Antibiotics<\/h1>\r\n<\/div>\r\n<div>\r\n\r\nDue to potential for development of resistance, topical antibiotics should be used as part of a treatment to treat localized infections and not as component of routine maintenance of chronic skin conditions.\r\n\r\n<\/div>\r\n<div>\r\n\r\nMupirocin: Bactericidal against MRSA, good Gm+ coverage. Excellent choice for impetigo as well as part of decolonization protocol for MRSA.\r\n\r\n<\/div>\r\n<div>\r\n\r\nFusidic acid: Bacteriostatic against Gm +, especially S. Aureus.\r\n\r\n<\/div>\r\n<div>\r\n\r\nErythromycin: Bactericidal against most Gm+ and C. acnes. Also has a significant anti-inflammatory effect.\u00a0 Used for acne and rosacea. Safe in pregnancy.\r\n\r\n<\/div>\r\n<div>\r\n\r\nClindamycin: Broad spectrum coverage, including anaerobic. Used for acne and rosacea. Safe in pregnancy. Bacteria readily develop resistance so must be used in combination (see above).\r\n\r\n<\/div>\r\n<div style=\"font-weight: 400\">\r\n\r\n&nbsp;\r\n\r\n<\/div>","rendered":"<div>\n<h1>OTC Topical Antibiotics<\/h1>\n<\/div>\n<div>\n<p>Bacitracin: Bactericidal against Gm+. Can develop allergic contact dermatitis with prolonged use.<\/p>\n<p>Polymyxin B: Bactericidal against Gm-. Often combined with bacitracin.<\/p>\n<p>Neomycin: Bactericidal against Gm+ and Gm-, good S. Aureus coverage. Can develop allergic contact dermatitis with prolonged use.\u00a0 Often combined with bacitracin and polymyxin B.<\/p>\n<\/div>\n<div>\n<h1>Prescription Topical Antibiotics<\/h1>\n<\/div>\n<div>\n<p>Due to potential for development of resistance, topical antibiotics should be used as part of a treatment to treat localized infections and not as component of routine maintenance of chronic skin conditions.<\/p>\n<\/div>\n<div>\n<p>Mupirocin: Bactericidal against MRSA, good Gm+ coverage. Excellent choice for impetigo as well as part of decolonization protocol for MRSA.<\/p>\n<\/div>\n<div>\n<p>Fusidic acid: Bacteriostatic against Gm +, especially S. Aureus.<\/p>\n<\/div>\n<div>\n<p>Erythromycin: Bactericidal against most Gm+ and C. acnes. Also has a significant anti-inflammatory effect.\u00a0 Used for acne and rosacea. Safe in pregnancy.<\/p>\n<\/div>\n<div>\n<p>Clindamycin: Broad spectrum coverage, including anaerobic. Used for acne and rosacea. Safe in pregnancy. Bacteria readily develop resistance so must be used in combination (see above).<\/p>\n<\/div>\n<div style=\"font-weight: 400\">\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"author":1682,"menu_order":10,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-1238","chapter","type-chapter","status-publish","hentry"],"part":1212,"_links":{"self":[{"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/chapters\/1238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/wp\/v2\/users\/1682"}],"version-history":[{"count":2,"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/chapters\/1238\/revisions"}],"predecessor-version":[{"id":1499,"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/chapters\/1238\/revisions\/1499"}],"part":[{"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/parts\/1212"}],"metadata":[{"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/chapters\/1238\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/wp\/v2\/media?parent=1238"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/pressbooks\/v2\/chapter-type?post=1238"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/wp\/v2\/contributor?post=1238"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/pedsdermprimer\/wp-json\/wp\/v2\/license?post=1238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}