{"id":3,"date":"2021-01-18T15:55:53","date_gmt":"2021-01-18T20:55:53","guid":{"rendered":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/2021\/01\/18\/main-body\/"},"modified":"2022-01-12T22:29:03","modified_gmt":"2022-01-13T03:29:03","slug":"main-body","status":"publish","type":"part","link":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/part\/main-body\/","title":{"raw":"Randomized Controlled Trials","rendered":"Randomized Controlled Trials"},"content":{"raw":"[pb_glossary id=\"704\"]RCTs[\/pb_glossary] are experimental studies that attempt to isolate the cause-and-effect relationship of an intervention on select outcomes. [pb_glossary id=\"704\"]RCTs[\/pb_glossary] recruit participants that meet specified inclusion and exclusion criteria, randomly allocate these participants to two or more intervention groups, and then follow them over time to monitor for outcomes of interest. High-quality [pb_glossary id=\"704\"]RCTs[\/pb_glossary] enable inferences regarding the effects of a treatment. However, deficiencies in the trial may introduce [pb_glossary id=\"193\"]bias[\/pb_glossary], obscuring the effect of the intervention.\r\n\r\nThis chapter will provide guidance in assessing [pb_glossary id=\"704\"]RCTs[\/pb_glossary] for risk of bias and its potential impact on the results, as well as the clinical relevance of the findings.","rendered":"<p><a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_3_704\">RCTs<\/a> are experimental studies that attempt to isolate the cause-and-effect relationship of an intervention on select outcomes. <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_3_704\">RCTs<\/a> recruit participants that meet specified inclusion and exclusion criteria, randomly allocate these participants to two or more intervention groups, and then follow them over time to monitor for outcomes of interest. High-quality <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_3_704\">RCTs<\/a> enable inferences regarding the effects of a treatment. However, deficiencies in the trial may introduce <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_3_193\">bias<\/a>, obscuring the effect of the intervention.<\/p>\n<p>This chapter will provide guidance in assessing <a class=\"glossary-term\" aria-haspopup=\"dialog\" aria-describedby=\"definition\" href=\"#term_3_704\">RCTs<\/a> for risk of bias and its potential impact on the results, as well as the clinical relevance of the findings.<\/p>\n<div class=\"glossary\"><span class=\"screen-reader-text\" id=\"definition\">definition<\/span><template id=\"term_3_704\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_3_704\"><div tabindex=\"-1\"><p>Randomized controlled trials are those in which participants are randomly allocated to two or more groups which are given different treatments.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><template id=\"term_3_193\"><div class=\"glossary__definition\" role=\"dialog\" data-id=\"term_3_193\"><div tabindex=\"-1\"><p>Systematic deviation of an estimate from the truth (either an overestimation or underestimation) caused by a study design or conduct feature. See the <a href=\"https:\/\/catalogofbias.org\/biases\/\">Catalog of Bias<\/a> for specific biases, explanations, and examples.<\/p>\n<\/div><button><span aria-hidden=\"true\">&times;<\/span><span class=\"screen-reader-text\">Close definition<\/span><\/button><\/div><\/template><\/div>","protected":false},"parent":0,"menu_order":2,"template":"","meta":{"pb_part_invisible":false,"pb_part_invisible_string":""},"contributor":[],"license":[],"class_list":["post-3","part","type-part","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/pressbooks\/v2\/parts\/3","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/pressbooks\/v2\/parts"}],"about":[{"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/wp\/v2\/types\/part"}],"version-history":[{"count":21,"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/pressbooks\/v2\/parts\/3\/revisions"}],"predecessor-version":[{"id":1881,"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/pressbooks\/v2\/parts\/3\/revisions\/1881"}],"wp:attachment":[{"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/wp\/v2\/media?parent=3"}],"wp:term":[{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/wp\/v2\/contributor?post=3"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.bccampus.ca\/rickyturgeon\/wp-json\/wp\/v2\/license?post=3"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}