4.12 Beta-1 Agonists

Dobutamine is a Beta-1 agonist.

Mechanism of Action:  Dobutamine stimulates Beta-1 receptors to increase heart rate, force of contraction, and conduction velocity.

Indications for Use: Dobutamine is used to treat cardiogenic shock and severe heart failure to increase contractility and cardiac output.

Nursing Considerations Across the Lifespan: Beta-1 agonists can safely be administered to pediatric clients, but doses must be adjusted according to weight. These medications are also safe in the older adult population, with no special dose adjustments for renal or liver insufficiency. Beta-1 agonists should not be given in pregnancy, if they can be avoided.

In IV administration, dilute concentration before administering. Continuously monitor electrocardiogram (ECG), blood pressure, cardiac output, and urine output during therapy. This drug can cause a marked increase in heart rate and blood pressure. Report all adverse reactions promptly, especially laboured breathing, angina, palpitations, and dizziness.

Patient Teaching & Education: The client should be instructed to inform the nurse immediately if they notice chest pain, shortness of breath, or numbness or tingling in the extremities.^[1]

Now let’s take a closer look at the dobutamine medication grid in Table 4.12.^[2][3] Because information about medication is constantly changing, nurses should always consult evidence-based resources to review current recommendations before administering specific medication.

Table 4.12 Dobutamine Medication Card