Chapter 10 Selected Diseases and Disorders of the Digestive System
10p14 Liver and Pancreas: Key Functions
Zoë Soon
The Liver: An Essential Organ
Overview
- Often overlooked but critically important for survival.
- Performs multiple vital functions for maintaining health and homeostasis.
Key Functions of the Liver:
1. Detoxification
- Breaks down alcohol and drugs.
- Prepares toxins for elimination from the body.
2. Blood Protein Composition Regulation
- Produces and regulates plasma proteins involved in:
- Clotting (e.g., fibrinogen, prothrombin).
- Maintaining blood fluidity.
- Maintains blood composition within tight limits for tissues’ needs.
3. Bile Production
- Produces bile, essential for digestion.
- Bile is transported via the left and right hepatic ducts.
- Stored in the gallbladder:
- Signaled to contract after eating.
- Pushes bile through the cystic duct into the common bile duct.
- Enters the duodenum (first part of the small intestine).
Role of Bile in Digestion
Fat Emulsification
- Bile emulsifies fats, breaking large fat droplets into smaller ones.
- Smaller droplets are easier for pancreatic enzymes to digest.
Pancreatic Enzymes
- Produced by the pancreas.
- Break down proteins and fats into smaller molecules.
- Facilitates absorption across the intestinal wall.
Absorption and Liver Processing
- Nutrients (amino acids, glucose, fats) are absorbed into the intestinal walls then into the bloodstream.
- Blood transports nutrients to the liver.
- The liver selects which components to store or send to tissues.
Importance of Liver Function
- Ensures nutrients are properly processed.
- Supplies the body with building blocks for tissue repair and energy production.
Summary
- The liver is central to metabolism, detoxification, clotting, and digestion.
- Proper liver function is essential for overall health and efficient nutrient utilization.