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Chapter 10 Selected Diseases and Disorders of the Digestive System

10p14 Liver and Pancreas: Key Functions

Zoë Soon

The Liver: An Essential Organ

Overview

  • Often overlooked but critically important for survival.
  • Performs multiple vital functions for maintaining health and homeostasis.

Key Functions of the Liver:

1.  Detoxification

  • Breaks down alcohol and drugs.
  • Prepares toxins for elimination from the body.

2.  Blood Protein Composition Regulation

  • Produces and regulates plasma proteins involved in:
    • Clotting (e.g., fibrinogen, prothrombin).
    • Maintaining blood fluidity.
  • Maintains blood composition within tight limits for tissues’ needs.

3.  Bile Production

  • Produces bile, essential for digestion.
  • Bile is transported via the left and right hepatic ducts.
  • Stored in the gallbladder:
    • Signaled to contract after eating.
    • Pushes bile through the cystic duct into the common bile duct.
    • Enters the duodenum (first part of the small intestine).

Role of Bile in Digestion

Fat Emulsification

  • Bile emulsifies fats, breaking large fat droplets into smaller ones.
  • Smaller droplets are easier for pancreatic enzymes to digest.

Pancreatic Enzymes

  • Produced by the pancreas.
  • Break down proteins and fats into smaller molecules.
  • Facilitates absorption across the intestinal wall.

Absorption and Liver Processing

  • Nutrients (amino acids, glucose, fats) are absorbed into the intestinal walls then into the bloodstream.
  • Blood transports nutrients to the liver.
  • The liver selects which components to store or send to tissues.

Importance of Liver Function

  • Ensures nutrients are properly processed.
  • Supplies the body with building blocks for tissue repair and energy production.

Summary

  • The liver is central to metabolismdetoxificationclotting, and digestion.
  • Proper liver function is essential for overall health and efficient nutrient utilization.

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