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4 Neutral trials: If the difference between interventions is not statistically significant, is there truly no difference?

Neutral trials (i.e. trials without a statistically significant difference in the primary outcome) should not all be interpreted equally, as they will differ in the degree in which they rule out a difference between interventions. It is important to be able to recognize that “no statistically significant difference” does not mean “no difference”.

Neutral trials are also sometimes referred to as “negative trials”.

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