Genodermatoses: Post-zygotic Mutations

Post-zygotic mutations occur after conception and lead to genetic change in only a subset of cells. Such changes are often referred to as mosaic conditions and often present on the skin with changes in a segmental pattern or in a Blashkoid pattern with lines and swirls. Examples of post-zygotic mutations include segmental NF, pigmentary mosaicism, and birthmarks such as port wine stains and epidermal nevi.