Genodermatoses

Genetic mutations can lead to a wide variety of skin changes that reflect the nature and timing of the genetic mutation. Given the nature of skin embryology, the skin provides a remarkable window into the source of timing of such mutations. Some genetic skin alterations lead to only minor or cosmetic skin changes while others are severe and life-limiting. A complete review of genodermatoses is clearly beyond the scope of this manual and fortunately, the vast majority of such conditions are rare. Nonetheless, a few key points and conditions are worth mentioning.