Nevus depigmentosus is a birthmark that presents as a hypopigmented macule or patch, measuring a few centimeters in diameter and with well-defined but irregular borders. It is most common on the trunk but can appear anywhere. Nevus depigmentosus might not be noticed at birth and become apparent at several years of age.

Nevus anemicus is an uncommon capillary malformation consisting of a localized area of vasoconstricted vessels. It appears as a hypopigmented patch with well defined but irregular borders.

Nevus depigmentosus and nevus anemicus can be differentiated clinically by applying pressure to the skin with a glass slide. A nevus anemicus will characteristically “disappear” into the surrounding skin. Another technique is to rub the skin overlying the area, a nevus anemicus will stay hypopigmented but a nevus depigmentosus will become pink like the surrounding skin. There is no treatment necessary for either of these lesions. If patients are bothered by the appearance make-up to camouflage the area can be helpful.