Chapter 6: Infections and Infestations
Viral Infections: Human Herpes Virus (HHV)
Herpes viruses are double-stranded DNA viruses that replicate in the cell nucleus. They often have the ability to cause latent infections which can appear at a later point in the patient’s life. The majority of patients with latent infections are asymptomatic. The important herpes viruses include HSV 1 and HSV 2, HHV 6 and 7, Varicella-Zoster virus, Cytomegalovirus, and Epstein Barr virus.
| HHV | Other Name | Clinical Significance |
| 1 | Herpes Simplex Virus 1 | Orolabial/gential herpes, herpetic whitlow, etc. |
| 2 | Herpes Simplex Virus 2 | Orolabial/gential herpes, herpetic whitlow, etc. |
| 3 | Herpes Simplex Virus 3 | Varicella (chickenpox), zoster (shingles) |
| 4 | Herpes Simplex Virus 4 | Mononucleosis, EBV-associated leukemia/lymphoma, Gianotti-Crosti, oral hairy leukoplakia, etc. |
| 5 | Herpes Simplex Virus 5 | Retinitis, mononucleosis-like infectious syndrome |
| 6 | Herpes Simplex Virus 6 | Roseola infantum, pityriasis rosea, drug reaction with eosinophilia and systemic symptoms (DRESS) |
| 7 | Roseolovirus | Pityriasis rosea, roseola infantum, drug reaction with eosinophilia and systemic symptoms (DRESS) |
| 8 | Kaposi Sarcoma-associated HHV | Kaposi Sarcoma |
