Autoimmunity
Autoimmunity Chapter Overview
Autoimmunity Chapter Overview
Morgan Alford and Dylan Mann
Chapter Learning Objectives
By the end of this chapter, you will be able to:
- Describe the mechanisms and components of the immune system and differentiate between innate and adaptive immune responses.
- Explain the structure, function, and classes of antibodies and how these features effect antibody affinity, avidity, and cross reactivity.
- Discuss disruptions in the immune systems and differentiate between hypersensitivities and autoimmune reactions.
- Highlight key mechanisms and manifestations of common autoimmune conditions such as Celiac Disease, Graves’ Disease, Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Vitiligo.
Autoimmunity is a condition in which the body’s immune system mistakenly attacks its own cells, tissues, or organs. A combination of genetic and environmental factors influence the development of autoimmunity. Autoimmune processes may manifest as one of many diseases, some of which are discussed in this chapter.
This chapter is subdivided into the following sections:
- Pre-test
- Immunity Overview
- Innate Immune Responses
- Adaptive Immune Responses
- Antibodies
- Disruptions in the Immune System
- Celiac Disease
- Rheumatoid Arthritis
- Vitiligo
- Graves’ Disease
- Systemic Lupus Eryhematosus
- Post-test
Abbreviations
| PAMPs | Pathogen associated molecular patterns |
| TLRs | Toll like receptors |
| PRRs | Pattern recognition receptors |
| NK cells | Natural killer cells |
| MHC | Major histocompatibility complex |
| APC | Antigen presenting cell |
| CTLs | Cytotoxic T lymphocytes |
| TCRs | T cell receptors |
| TH lymphocytes | T helper lymphocytes |
| BCR
MALT Treg Ig SLE SCID HLA GFD anti-CPP NSAIDs RA UV TRH TSH ANAs |
B cell receptor
Mucosa associated lymphoid tissue T regulatory Immunoglobulin Systemic lupus Eryhematosus Severe combined immunodeficiency Human leukocyte antigen Gluten free diet Anti-cyclic citrullinated peptide Non-steroidal anti-inflammatory agents Rheumatoid arthritis Ultraviolet Thyrotropin releasing hormone Thyroid stimulating hormone Anti nucleic antibodies |
