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Cirrhosis

Histopathology of Cirrhosis

Jennifer Kong and Yimei Qin

Learning Objectives

By the end of this section, you will be able to:

  • List the effects of scar tissue on the flow of bile and blood in the liver
  • correlate the microscopic findings of cirrhosis with the nodules seen by the naked eye

The obvious nodular pattern – seen in gross specimens – is also evident in the histology of cirrhotic livers.  The deposition of stiff, fibrotic, scar tissue interrupts the normally homogenous pattern of hepatocytes organized into lobules.   This scar tissue will cause resistance to both blood flowing into the liver (esp portal vein) and bile leaving the liver (i.e. bile ducts).   There is a limited amount of regeneration of tissues to try to replace the damaged hepatocytes, but they are outpaced by the scar tissue deposition.

Histopathology of liver cirrhosis presented by Yimei Qin using specimen from Dr. Gang Wang’s private collection. 

License

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Pathology Copyright © 2022 by Jennifer Kong and Helen Dyck is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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